The recruitment of Histone deacetylase (HDACS).... O a. Enzymatically adds acetyl groups to E2f target genes. b. O D. Forms a complex with E2f to activate transcription. OC. Remodels chromatin into a repressed state. O d. Forms a complex with hyperphosphorylated pRb.
Q: DNA is the cellular repository of genetic information, andproteins are synthesized from RNA…
A: The branch of biological science focusing on the study of variations of genes, genes as a whole, and…
Q: A researcher found that she could increase phosphorylation of amino acids adjacent to methylated…
A: Histone Phosphorylation It is associated with transcriptional activation. It takes place with the…
Q: Which statement/s is/are TRUE about transcription? A. During transcription, DNA polymerase binds to…
A: Transcription is the process that involved production of RNA from the DNA. this process occurs will…
Q: Discuss the role of chromatin proteins in regulating gene expression. How does the three-dimensional…
A: Chromatin is a part of the nucleus of the eukaryotic cell. This highly organized complex of DNA and…
Q: Gene Regulation and Breast Cancer Researchers have found that breast cancer cells commonly express…
A: The transcription factor ETS1 is encoded by the gene ETS1 to the ETS family of transcription…
Q: Combinatorial control of transcription factors refers to the phenomenon that: O A) small effector…
A: Transcription is the process in which the DNA is converted into mRNA and forms the part of the…
Q: Can one transcription factor sometimes act as a repressor and sometimes act as an activator? a. Yes,…
A: Transcription factors are proteins that bind to neighbouring DNA and help switch particular genes…
Q: A chromatin-remodeling complex may a. change the locations of nucleosomes. b. evict nucleosomes from…
A: Nucleosome is the packaging unit in eukaryotes. It is a fundamental subunit of chromatin.…
Q: The retinoblastoma tumor suppressor gene Rb (RB1) codes forthe retinoblastoma protein (pRB). pRB…
A: Retinoblastoma is a tumor suppressor gene during cancer progression, loss of function of tumor…
Q: Transcriptional activation of eukaryotic genes involves which of the following events? a. Changes in…
A: Nucleosome is the packaging unit in eukaryotes. It is a fundamental subunit of chromatin.…
Q: Changes in chromatin packing correlate with changes in gene expression in most cells. Why do you…
A: The chromosomes resemble a mass of extremely fine tangled string called chromatin, consisting of DNA…
Q: Suppose that you have cancer cell line X was treated with drug Y to increase the expression levels…
A: Given, X is a cancer cell line which was treated with a drug Y. It resulted in the increase of…
Q: Cancer cells removed from a patient's tumor have increased gene expression of several hundred genes…
A: Cancer Cancer if a kind of disorder which caused by several means like drug, radiation, malfunction…
Q: Epigenetic control of gene expressiona. is hereditary. c. adds methyl groups to cytosine.b. locks…
A: Stem cells are cells that can grow not other cells in the body. Stem cells are of two types one is…
Q: What is the effect of histone acetylation? O the destruction of the histone O the tightening of the…
A: Histone acetylation is a process in which the side chain of the positively charged amino acids…
Q: How is transcription directly controlled in eukaryotic cells? a. through the use of phosphorylation…
A: Transcription refers to a process that transcribes the DNA molecule into a molecule called RNA which…
Q: Suppose that you have cancer cell line X was treated with drug Y to increase the expression levels…
A: The genes that suppress tumors are ordinary genes, which delay cell division, fix DNA errors or tell…
Q: Explain, and draw a diagram to show, how acetylation or phosphorylation could change the binding…
A: In eukaryotic organisms, the DNA wrap around the histone proteins to form a packaged structure…
Q: The conversion of euchromatin into heterochromatin involvesa. the formation of more nucleosomes.b.…
A: Chromatin is eukaryotes is the packaged form of DNA. DNA is packaged into coils with the help of…
Q: Describe how chromatin is remodeled to regulate gene expression in eukaryotes
A: Eukaryotes =Eu(true) +Karyon (nucleus). Organism with true nucleus is known as Eukaryotes.
Q: How does adding a methyl or acetyl group to a histone protein alter gene activity?A. A methyl group…
A: Histones are proteins. It gives structural support and shape to a chromosome.
Q: Chromatin remodeling is affected by two processes, DNA methylation and a. base substitution b.…
A: Chromatin remodeling is the dynamic modification of chromatin architecture to allow access of…
Q: What is cell differentiation? Discuss the role of myogenic bHLH proteins in the differentiation of…
A: Proteins are the building blocks of the body and they are composed of chains of amino acids. Amino…
Q: Cell division cycle mutations render the mutants unable to continue the cell cycle. This…
A: Cellular checkpoint prevents the progression of cell cycle if the cell is unfavorable (such as…
Q: Mutations that occur at the end of a gene may alter the sequence of the gene and prevent…
A: Transcription is one of the defined steps of gene expression and precisely refers to the formation…
Q: What does the statement above mean
A:
Q: Suppose that you have cancer cell line X was treated with drug Y to increase the expression levels…
A: Cancer cell lines are usually generated by isolating them from the cancer tissue itself. These cells…
Q: Based on my your observations, describe the role of the transcription factors and the regulatory…
A: Central dogma involves a method where RNA formed from DNA , and DNA shows heterocatalytic neture,…
Q: Suppose MYC regulates gene X by recruiting DNA methyltransferases (DNMTS). Which of the following…
A: cis regulatory elements are regions of non coding DNA which regulate transcription of neighbouring…
Q: Experiments show that mutations at gene E lead to non-repressible transcription of trp genes. Why?
A: Ans: Tryptophan operon: It is the type of repressible operon, which is used in cells for the…
Q: Which of the following is an example of post-transcriptionalcontrol of gene expression?(A) the…
A: Post-transcriptional regulation is the gene expression control at the biological process common in…
Q: A signaling pathway causes a transcription factor binding to a particular promoter. What effect does…
A: Answer- Signaling transduction is the process by which any specific external physical or chemical…
Q: Can one transcription factor sometimes act as a repressor and sometimes act as an activator? O a.…
A: We are authorized to answer only one question at a time, since you have not mentioned which question…
Q: Cells were isolated from another cancerous tumor, and it was found that the DNA coding for Ets1 in…
A: Transcription proteins by attaching to a particular DNA (deoxyribonucleic acid) regulate the rate of…
Q: Histones can be modified to turn genes on and off. Which type of chromatin is associated with…
A: Chromatin is a complex form of DNA molecule and Histone protein which was found in eukaryotic…
Q: Suppose a chemist develops a new drug that neutralizes the positive charges on the tails of histone…
A: Nucleosome is a basic structural and functional repeating unit of chromatin. It is also a unit of…
Q: s chromatin remodeling regulate gene transcripti
A: Transcription is the process of synthesizing an mRNA molecule from the DNA sequence of a gene. This…
Q: Research genetic diseases and find one that interests you. In your initial response, describe the…
A: DNA : It is the name for the molecule that carries genetic instructions in all living things.
Q: Which of the following is NOT a mechanism of control of gene expression Group of answer choices a.…
A: The regulation of gene expression is controlled by various methods that includes control of…
Q: Researchers have found that breast cancer cells commonly express a transcription factor known as…
A: Cancer, also termed as malignancy, is a group of disease that is caused by abnormal growth of cells.…
Q: Which is the expected outcome following the deacetylation of histones?
A: Ans - a) Coiling of chromatin, preventing it from being accessed by the transcriptional machinery.…
Q: 1. Where would the RNA polymerase II bind this piece of DNA = region B 2. What DNA sequence would…
A: 1. DNA polymerase 2 binds with the piece of DNA - B & A. Explanation - Region B is the - 80 CAAT…
Q: What is a possible outcome of the addition of a transcription factor such as Myod to the nucleus of…
A: Transcription factors are the proteins which are produced from certain genes and are utilised for…
Q: Experiments show that mutations at gene E lead to non-repressible transcription of trp genes. Why
A: In bacterial cells, the tryptophan operon is responsible for the synthesis of tryptophan amino acid.…
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
- Which of these is NOT true of nucleosomes? A. Some post-translational modifications to histone proteins serve as binding sites for transcription factors. B. The position of nucleosomes is fixed on the genome and can not be changed. C. The position and post-translational modifications of histones can be inherited through mitosis. D. The binding between DNA and histone proteins can be disrupted by post-translational modifications.Which of the following does NOT pertain to the myoblast-determining gene 1?*a. It is a master gene.b. It is a silencing gene.c. It produces a transactivating protein.d. It activates its own gene. Gene silencing involves which type of histone modification?* a. acetylation of histone 4 b. dimethylation of histone 3 c. trimethylation of histone 4 d. trimethylation of histone 3 Given the required environment, the totipotency of the nucleus can allow which of the following?* a. a committed cell to undergo dedifferentiation b. a committed cell to undergo terminal differentiation c. a terminally differentiated cell to produce a complete organism d. a terminally differentiated cell to produce specific types of tissues An induced pluripotent cell is described by which of the following?* a. It is a committed cell that undergoes redifferentiation. b. It is a committed cell that undergoes dedifferentiation. c. It is a terminally…Regulation of Gene Expression by Chromatin Modification is Local and Dynamic! What does the statement above mean?
- (46) A mutated form of protein p5x is found in patients with squamous cell carcinoma. In vitro studies show that the normal p5x molecule binds to DNA, and neoplastic cells accumulate in the G0 phase of the cell cycle. In contrast, the mutated form of p5x does not bin d to DNA. These finding are most characteristics of which of the following? (A) Growht factor receptors (B) GTP-binding protein (C) Nonreceptor tyrosine kinases (D) Oncogene proteins (E) Tumor suppressor gene proteinsA researcher found that she could increase phosphorylation of amino acids adjacent to methylated amino acids in histone tails. What would she see? Select one: O a. inactivation of the selected genes O b. decreased binding of transcription factors O c. decreased chromatin condensation O d. increased chromatin condensationIn eukaryotes, chromatin remodeling plays an important role is gene regulation. This is because a. repositioning of the nucleosomes makes DNA accessible to transcription regulatory proteins b. the nucleosomes contain important regulatory regions c. chromatin remodeling activates gene expression d. chromatin remodeling represses gene expression
- Changes in chromatin packing correlate with changes in gene expression in most cells. Why do you think this is the case?After the initial Actualization of the Cit+ phenotype, there was another alteration to the A-3 genome that resulted in increased growth (e.g. Refinement). What explained the increase in growth rate in response to Refinement? A. Increase number of transporters localized to the plasma membrane. B. Increased ability to metabolize glucose. C. Increased citric acid cycle activity. D. Altered promoter activity resulting in constitutive gene expression.You add a chemical to a cell that prevents all of the chromatin from uncoiling so that the chromosomes remain highly coiled, even after the completion of mitosis. If you add a transcription factor that triggers the transcription of mRNA for the protein Pitx in this situation what would happen. Group of answer choices A)All transcription of Pitx is stopped by the transcription factor B)Nothing because the Pitx gene is already being transcribed at the maximum ratea C)Nothing, because the Pitx gene cannot be transcribed in this highly coild state D)The amount of transcription of Pitx is greatly increasedt
- You are studying the M-cyclin. You treat mitotic cells with an inhibitor of the proteasome and find that M-cyclin is no longer degraded and that this prolongs mitosis. You also find that in the presence of the inhibitor, M-cyclin is now running slower/larger in a Western than you have previously doserved. In 1-2 sentences, explain why this might be happening.For each statement about gene expression mechanisms, choose the correct end to the sentence. For each gene, the template strand for transcription is determined by…. The direction of translation is determined by…… The tissue-specificity of protein production is determined by…. choices: a. location of the start codon b. location of the promoter c. direction of polymerization by RNA polymerase d. none of these e. direction of movement of ribosomes f. overall orientation of the chromosomeVinblastine is a standard chemotherapeutic drug used to treat cancer. Because it interferes with the assembly of microtubules, its effectiveness must be related to Select one: a. inhibition of DNA synthesis. O b. myosin denaturation and inhibition of cleavage furrow formation. c. suppression of cyclin production. Od. inhibition of regulatory protein phosphorylation. O e. disruption of mitotic spindle formation. Next page