The principle pathway for transport of lysosomal hydrolases from the trans-Golgi network (pH 6.6) to the late endosomes (pH 6.0) and for recycling of Mannose-6-Phosphate (M6P) receptors back to the Golgi depends on the pH difference between those two compartments. From what you know about M6P-receptor binding and recycling pathways for delivery of material to lysosomes, describe the consequences of changing the pH in those two compartments. a) What would happen if the pH in the late endosomes was raised to pH 6.6? complete the sentence by choosing one for bolded choices. The M6P-receptor would (fail in/ succeed in) releasing its associated cargo and these proteins would be recycled back to the (Smooth ER/Trans-Golgi-compartment/rough ER). As a result, ("proteosomal"/ "endosomal"/ "lysosomal) proteins would fail to be delivered to the ("endosomal/lysosomal/ proteosomal)compartment and would accumulate in the ("TGN/Nucleus/Smooth ER.)
1. The principle pathway for transport of lysosomal hydrolases from the trans-Golgi network (pH 6.6) to the late endosomes (pH 6.0) and for recycling of Mannose-6-Phosphate (M6P) receptors back to the Golgi depends on the pH difference between those two compartments. From what you know about M6P-receptor binding and recycling pathways for delivery of material to lysosomes, describe the consequences of changing the pH in those two compartments.
a) What would happen if the pH in the late endosomes was raised to pH 6.6? complete the sentence by choosing one for bolded choices.
The M6P-receptor would (fail in/ succeed in) releasing its associated cargo and these proteins would be recycled back to the (Smooth ER/Trans-Golgi-compartment/rough ER). As a result, ("proteosomal"/ "endosomal"/ "lysosomal) proteins would fail to be delivered to the ("endosomal/lysosomal/ proteosomal)compartment and would accumulate in the ("TGN/Nucleus/Smooth ER.)
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