The piRNA, miRNA and RNAi pathways are all similar and may have evolved from some early function of small RNAs in an ancestral cell. The piRNA pathway seems a bit unique in several ways however. Name two distinct features that are unique to the piRNA pathway when compared to the miRNA and the RNAi pathwa

The piRNA, miRNA and RNAi pathways are all similar and may have evolved from some early function of small RNAs in an ancestral cell. The piRNA pathway seems a bit unique in several ways however. Name two distinct features that are unique to the piRNA pathway when compared to the miRNA and the RNAi pathwa

Name: The piRNA, miRNA and RNAi pathways are all similar and may have evolve
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Description: The piRNA, miRNA and RNAi pathways are all similar and may have evolved from some early function of small RNAs in an ancestral cell. The piRNA pathway seems a bit unique in several ways however. Name two distinct features that are unique to the piRNA

Biology (MindTap Course List)

11th Edition

ISBN:9781337392938

Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Chapter13: Gene Expression

Section: Chapter Questions

Problem 8TYU: Which of the following is/are typically removed from pre-mRNA during nuclear processing in...

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Consider the following sequence fragment of an mRNA. Which of the miRNAS below would be competent for gene silencing? 5'-AUGCAAGCAUUGGCCAAGCUU-3' 5'-AUGCAAGCAUUGGCCAAGCUU-3 5'-UACGUUCGUAACCGGUUCGAA-3' 5'-AAGCUUGGUUAAUGCUUGCAU-3' 5'-UUCGAACCAAUUACGAACGUA-3' 3'-UUCGAACCAAUUACGAACGUA-5 3'-AUGCAAGCAUUGGCCAAGCUU-5'
What are the differences between miRNA and siRNA? (Select all that apply.) OmiRNAs carry the genetic information from the DNA in the nucleus directly to the cytoplasm, and siRNAs are involved in the degradation of specific mRNA molecules. miRNAs are from 22 to 30 bases long, and siRNAs are 22 bases long. O miRNAs carry the genetic information from the DNA in the nucleus directly to the cytoplasm, and siRNAs help with the processing of the initial mRNA transcribed from DNA into a mature form. miRNAs prevent translation of certain mRNAs, and siRNAs are involved in the degradation of specific mRNA molecules. miRNAs are 20 to 22 bases long, and siRNAs are from 20 to 30 bases long.
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A particular mature miRNA (microRNA) in mice has sequence 5'-UUCCCUGAGACCUCAAGUGUGA-3'. a. If you wanted to predict which mouse mRNAs are regulated by this miRNA, what would you look for? Choose one or more. i. mRNA sequence the same as the miRNA sequence ii. mRNA sequence complementary to the miRNA sequence iii. mRNA sequence including a RISC binding site iv. mRNA sequence including 5'-CUCAGGGAA-3' v. mRNA sequence including 5'-UUCCCUGAG-3' b. Your sequence analysis predicts that 200 mRNAs may be targets of this miRNA. You engineer mouse cells that produce an excess of this miRNA. For the real targets, we predict that in these cells over-expressing the miRNA, compared to the unmodified cells. Choose one or more, and explain. i. The target gene is deleted in cells with an excess of the miRNA ii. The target is translated less in cells with an excess of the miRNA iii. The target is translated more in cells with an excess of the miRNA iv. There is more of the target mRNA in cells with an…
A double-stranded RNA has been generated by release/splicing out of an intron within the nucleus...outline the pathway taken to generate microRNA and its action on the shutdown of protein biosynthesis
While miRNA response elements (MREs) may be located anywhere within an mRNA, they are most often found outside the coding region in the 5 or 3 UTR. Explain why this is likely the case given that miRNAs often target more than one mRNA.
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