An rRNA binds to a snoRNP that contains a C/D box snoRNA.What type of covalent modification would you expect this rRNA toundergo? Would it be methylated or pseudouridylated, or both?
An rRNA binds to a snoRNP that contains a C/D box snoRNA.What type of covalent modification would you expect this rRNA toundergo? Would it be methylated or pseudouridylated, or both?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
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An rRNA binds to a snoRNP that contains a C/D box snoRNA.
What type of covalent modification would you expect this rRNA to
undergo? Would it be methylated or pseudouridylated, or both?
Expert Solution
Step 1
Small nucleolar RNAs (SnoRNAs) are metabolically stable RNAs that are abundantly present in nucleolus.
The snoRNA gets associated with proteins to form ribonucleoproteins (snoRNP). The snoRNAs are noncoding RNAs and are involved in functions like methylation and pseudouridylation.
The two main classes of snoRNAs include:
- One group carries box C (RUGAUGA) and D (CUGA) (C/D box)
- Other group contains box H (ANANNA) and ACA elements (H/ACA box)
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