the Mode of Inheritance (MOI) exercises. Focus on determining the values in the colored cells. Your solutions should read as prose, not simply computations. I have provided values for two MOIs discussed in the lecture, Autosomal Dominant MOI, and X-linked Recessive where the father is affected and the mother is homozygous unaffected. Sometimes, there is confusion regarding defining the disease allele and wild-type allele for a specific mode of inheritance. In this worksheet, you'll note that the D allele is the disease allele for the Autosomal Dominant mode of inheritance. However, it is also the disease allele for the Sex-Linked Recessive mode of inheritance, where the father is affected. The point is, any letter or symbol can represent a disease allele or wild-type allele as long as you define its meaning. For example, I may user to be the disease allele in an Autosomal Recessive mode of inheritance, and R to be the wild-type allele, or vice versa, as long as I write something like: r = disease allele, R = Wild-type allele.
the Mode of Inheritance (MOI) exercises. Focus on determining the values in the colored cells. Your solutions should read as prose, not simply computations. I have provided values for two MOIs discussed in the lecture, Autosomal Dominant MOI, and X-linked Recessive where the father is affected and the mother is homozygous unaffected. Sometimes, there is confusion regarding defining the disease allele and wild-type allele for a specific mode of inheritance. In this worksheet, you'll note that the D allele is the disease allele for the Autosomal Dominant mode of inheritance. However, it is also the disease allele for the Sex-Linked Recessive mode of inheritance, where the father is affected. The point is, any letter or symbol can represent a disease allele or wild-type allele as long as you define its meaning. For example, I may user to be the disease allele in an Autosomal Recessive mode of inheritance, and R to be the wild-type allele, or vice versa, as long as I write something like: r = disease allele, R = Wild-type allele.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:the Mode of Inheritance (MOI) exercises. Focus on
determining the values in the colored cells. Your
solutions should read as prose, not simply computations.
I have provided values for two MOIs discussed in the
lecture, Autosomal Dominant MOI, and X-linked
Recessive where the father is affected and the mother is
homozygous unaffected.
Sometimes, there is confusion regarding defining the
disease allele and wild-type allele for a specific mode of
inheritance. In this worksheet, you'll note that the D
allele is the disease allele for the Autosomal Dominant
mode of inheritance. However, it is also the disease allele
for the Sex-Linked Recessive mode of inheritance, where
the father is affected.
The point is, any letter or symbol can represent a disease
allele or wild-type allele as long as you define its
meaning. For example, I may use r to be the disease allele
in an Autosomal Recessive mode of inheritance, and R to
be the wild-type allele, or vice versa, as long as I write
something like:
r = disease allele,
R = Wild-type allele.

Transcribed Image Text:Autosomal
Dominant
Homozygous
Lethal
X-linked
Recessive 01
F₂
Po
F₁
F₂
Po
Father alleles
Genotype
DD
Dd
dd
Father Genotype:
Father Phenotype:
Punnett Square
Father alleles
Genotype
DD
Dd
dd
Father Genotype:
Father Phenotype:
Punnett Square
Father Alleles
Genotype
DD
Dd
dd
Father Genotype:
Father Phenotype:
Punnett Square
Probability
Affected
Probability
Affected
Probability
DY
Affected
Phenotype
Affected
Unaffected
Mother Genotype:
Mother
Phenotype:
Phenotype
Affected
Unaffected
Mother alleles
Mother Genotype:
Mother
Phenotype:
Phenotype
Affected
Unaffected
Probability
Mother Genotype:
Unaffected
Mother
Phenotype:
Mother alleles
Probability
Unaffected
Probability
dd
Unaffected
Mother alleles
d
d
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