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the Mode of Inheritance (MOI) exercises. Focus on determining the values in the colored cells. Your solutions should read as prose, not simply computations. I have provided values for two MOIs discussed in the lecture, Autosomal Dominant MOI, and X-linked Recessive where the father is affected and the mother is homozygous unaffected. Sometimes, there is confusion regarding defining the disease allele and wild-type allele for a specific mode of inheritance. In this worksheet, you'll note that the D allele is the disease allele for the Autosomal Dominant mode of inheritance. However, it is also the disease allele for the Sex-Linked Recessive mode of inheritance, where the father is affected. The point is, any letter or symbol can represent a disease allele or wild-type allele as long as you define its meaning. For example, I may user to be the disease allele in an Autosomal Recessive mode of inheritance, and R to be the wild-type allele, or vice versa, as long as I write something like: r = disease allele, R = Wild-type allele.

the Mode of Inheritance (MOI) exercises. Focus on determining the values in the colored cells. Your solutions should read as prose, not simply computations. I have provided values for two MOIs discussed in the lecture, Autosomal Dominant MOI, and X-linked Recessive where the father is affected and the mother is homozygous unaffected. Sometimes, there is confusion regarding defining the disease allele and wild-type allele for a specific mode of inheritance. In this worksheet, you'll note that the D allele is the disease allele for the Autosomal Dominant mode of inheritance. However, it is also the disease allele for the Sex-Linked Recessive mode of inheritance, where the father is affected. The point is, any letter or symbol can represent a disease allele or wild-type allele as long as you define its meaning. For example, I may user to be the disease allele in an Autosomal Recessive mode of inheritance, and R to be the wild-type allele, or vice versa, as long as I write something like: r = disease allele, R = Wild-type allele.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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the Mode of Inheritance (MOI) exercises. Focus on determining the values in the colored cells. Your solutions should read as prose, not simply computations. I have provided values for two MOIs discussed in the lecture, Autosomal Dominant MOI, and X-linked Recessive where the father is affected and the mother is homozygous unaffected. Sometimes, there is confusion regarding defining the disease allele and wild-type allele for a specific mode of inheritance. In this worksheet, you'll note that the D allele is the disease allele for the Autosomal Dominant mode of inheritance. However, it is also the disease allele for the Sex-Linked Recessive mode of inheritance, where the father is affected. The point is, any letter or symbol can represent a disease allele or wild-type allele as long as you define its meaning. For example, I may use r to be the disease allele in an Autosomal Recessive mode of inheritance, and R to be the wild-type allele, or vice versa, as long as I write something like: r = disease allele, R = Wild-type allele.
Transcribed Image Text:the Mode of Inheritance (MOI) exercises. Focus on determining the values in the colored cells. Your solutions should read as prose, not simply computations. I have provided values for two MOIs discussed in the lecture, Autosomal Dominant MOI, and X-linked Recessive where the father is affected and the mother is homozygous unaffected. Sometimes, there is confusion regarding defining the disease allele and wild-type allele for a specific mode of inheritance. In this worksheet, you'll note that the D allele is the disease allele for the Autosomal Dominant mode of inheritance. However, it is also the disease allele for the Sex-Linked Recessive mode of inheritance, where the father is affected. The point is, any letter or symbol can represent a disease allele or wild-type allele as long as you define its meaning. For example, I may use r to be the disease allele in an Autosomal Recessive mode of inheritance, and R to be the wild-type allele, or vice versa, as long as I write something like: r = disease allele, R = Wild-type allele.
Mode of Generation Information for determining F1 and F2 genotype and phenotype probabilities Inheritance Autosomal Dominant Autosomal Recessive Po F₁ F₂ Po F₁ Father Genotype: Father Phenotype: Punnett Square Father alleles Genotype DD Dd dd Punnett Square Father alleles Genotype DD Dd dd Father Genotype: Father Phenotype: Punnett Square Father alleles Genotype DD Dd dd Punnett Square DD Affected D D Probability 0 0 D d Probability 0.25 0.5 0.25 Unaffected Probability Mother Genotype: Mother Phenotype: Mother alleles d Dd Dd Phenotype Affected Unaffected D DD Dd Mother alleles Phenotype Affected Unaffected Mother Genotype: dd Unaffected Mother Phenotype: Phenotype Affected Unaffected Probability 1 0 d Dd Dd Mother alleles Probability 0.75 0.25 d Dd dd Affected Mother alleles Probability
Transcribed Image Text:Mode of Generation Information for determining F1 and F2 genotype and phenotype probabilities Inheritance Autosomal Dominant Autosomal Recessive Po F₁ F₂ Po F₁ Father Genotype: Father Phenotype: Punnett Square Father alleles Genotype DD Dd dd Punnett Square Father alleles Genotype DD Dd dd Father Genotype: Father Phenotype: Punnett Square Father alleles Genotype DD Dd dd Punnett Square DD Affected D D Probability 0 0 D d Probability 0.25 0.5 0.25 Unaffected Probability Mother Genotype: Mother Phenotype: Mother alleles d Dd Dd Phenotype Affected Unaffected D DD Dd Mother alleles Phenotype Affected Unaffected Mother Genotype: dd Unaffected Mother Phenotype: Phenotype Affected Unaffected Probability 1 0 d Dd Dd Mother alleles Probability 0.75 0.25 d Dd dd Affected Mother alleles Probability
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