"Gain of function" mutations are generally dominant because one copy in a diploid organism is sufficient to alter the normal phenotype. True False Submit Request Answer
"Gain of function" mutations are generally dominant because one copy in a diploid organism is sufficient to alter the normal phenotype. True False Submit Request Answer
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:"Gain of function" mutations are generally dominant because one copy in a diploid organism is sufficient to alter the normal phenotype.
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Part A
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Assume that a mutation occurs in the gene responsible for the production of hexosaminidase A, such that only about 50% of the enzyme activity is found in the heterozygote compared
with a homozygous normal individual. If heterozygotes are phenotypically normal, we would say that the mutant allele is recessive to its normal allele.
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Gain of Function: It is a type of mutation in which the altered gene product has a new molecular function or new pattern of gene expression.
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