Hi, I'm having trouble with my study guide for my upcoming genetics exam. If someone could please help with work shown and an explanation it would help so much! Thank you!!
1a. The pedigree below represents inheritance of rare condition (filled symbols used for affected individuals). Test the hypothesis of X-linked dominant inheritance by assigning alleles (A or a) to sex chromosomes of all individuals in generations I and II. Does the X-linked dominant hypothesis agree with the data? It not, indicate all at least 2 individuals by generation and number (e.g. II-8) that are not consistent with the genotype you’ve proposed for the individuals in generation I.
1b. Test the hypothesis of autosomal dominant inheritance by assigning alleles (A or a) to autosomes of all individuals in the pedigree (generations I – IV). Does the autosomal dominant hypothesis agree with the data? It not, indicate all individuals by generation and number (e.g. II-8) that are not consistent with the genotype you’ve proposed for the individuals in generation I.
1c. If individuals III-4 and III-5 have another son, what are the chances this son will be affected?
1d. Given that individual IV-1 is affected, how far back can the source of this condition be traced? In other words, what individual was the oldest source of the allele that causes the condition?
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