Question 7The malate transporter in the mitochondrial inner membrane is involved in two important biochemical processes: one catabolic, and one anabolic. What are they?Transport of NAD* from glycolysis from the cytosol to the matrix for oxidative phosphorylation, and the last step of glycolysisO A.The citric acid cycle, and the last step of glycolysisOB.The glycerol 3-phosphate shuttle system, and the first gluconeogenesis bypassTransport of FADH, from beta oxidation from the cytosol to the matrix for oxidative phosphorylation, and the first gluconeogenesis bypassOF Transport of NADH from glycolysis from the cytosol to the matrix for oxidative phosphorylation, and the first gluconeogenesis bypass

Malate-Aspartate shuttle is present on the inner membrane of mitochondria.

Answered: The malate transporter in the…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Maximal production of ATP from glucose involves the reactions of glycolysis, the citric acid cycle, and the electron transport chain. Which of these reactions requires O2, and why? Which, in certain organisms or physiological conditions, can proceed in the absence of O2?
Look at the diagram of the mitochondrial electron transport chain below and answer the questions that follow Ubiquinone Membrane Z Complex I Complex III Y Complex I| Succinate Fumarate H,0 NAD NADH There are 2 names for the component in the orange circle labelled Y, they are: and The name of the component X in the red circle is The membrane labelled Z is the membrane Which component accepts electrons from complex 1?
The following two reactions are coupled in the last step of glycolysis (catalyzed by the enzyme pyruvate kinase). РЕР + Н.О € Руr + Pi ADP + Pi → ATP + H2O AG° = -14.8 kcal/mol AG° = +7.3 kcal/mol D) The steady-state concentrations of ATP, ADP, and pyruvate in human erythrocytes are 2.24 mM, 0.25 mM, and 0.051 mM, respectively. What would be the concentration of PEP in these cells if the coupled reaction was at equilibrium?
Which of the following conditions must be met within the cell In order for the enzyme pyruvate carboxylase to be activated? Select all that apply. NADP+ levels must be high Phosphofructokinase must be in the activated R-state Beta-oxidation of fatty acids happening in the mitochondrial matrix AMP levels must be high ATP levels must be high
Dinitrophenol (DNP) is a lipid soluble H+ binding drug that equalizes the H+ concentration across the inner mitochondrial membrane. Which of the following would you predict to occur upon addition of DNP to a cell? Halt in both pyruvate oxidation and ATP synthesis Halt in pyruvate oxidation and continuation in ATP synthesis Continuation in pyruvate oxidation and halt in ATP synthesis Continuation in both pyruvate oxidation and ATP synthesis
The intracellular use of glucose and glycogen is tightly regulated at four points. To compare the regulation of glycolysis when oxygen is plentiful and when it is depleted, consider the utilization of glucose and glycogen by rabbit leg muscle in two physiological settings: a resting rabbit and a rabbit that saw its mortal enemy, the coyote, and is dashing to its burrow. For each setting determine the relative levels of the following metabolites: Metabolite Resting.rabbit Dashing rabbit AMP ( Select) [ Select ) ATP ( Select) ( Select ) Citrate [ Select) ( Select ) Acetyl-CoA [ Select } ( Select ) >
in the mitochondria pyruvate is converted into acetyl CoA so then acetyl CoA make its way to the TCA cycle and produces energy sources for oxidative phosphorylation. Pyruvate oxidation transforms pyruvate, a three-carbon molecule, into acetyl, a two-carbon molecule linked to Coenzyme A, generating NADH and releasing one carbon dioxide molecule in process the citric acid cycle is fundamental because runs on acetyl CoA as its fuel. i need more explanantion
During periods of intense physical exercise, the demand for ATP in muscle tissue increases dramatically. L-lactic acid fermentation accounts for almost all of the ATP production in rabbit leg muscle and turkey flight muscle, respectively. A pair of processes, phosphoglycerate kinase and pyruvate kinase, are involved in the formation of ATP during the payout phase of glycolysis. Assume that the enzyme lactate dehydrogenase is absent from skeletal muscle. Could it withstand rigorous physical activity, that is, could it create large amounts of ATP at a rapid pace via the process of glycolysis? Explain.
Consider a liver cell carrying out the oxidation of glucose and fatty acids under aerobic conditions. Then, a very potent and specific inhibitor of the mitochondrial ATP synthase is added, completely inhibiting this enzyme. What will happen to the rate of the citric acid cycle? No change in the rate of the citric acid cycle O Increased due to the demand for reduced electron carriers to power reactions instead of ATP O Increased due to an accumulation of protons in the mitochondrial intermembrane space Reduced due to the accumulation of the products of the cycle that act as feedback inhibitors O Reduced as some enzymes of the cycle share the same active site as ATP synthase and will therefore be inhibited
One consequence of ethanol addiction is fatty liver disease, an illness in which liver cells accumulate large amounts of triacylglycerols, the esters derived from glycerol and fatty acids. Ethanol is oxidized in the cytoplasm of liver cells by alcohol dehydrogenase and aldehyde dehydrogenase to yield acetate and 2 NADH. Acetate is then transported into the mitochondrion, where it is converted to acetyl-CoA and metabolized in the citric acid cycle. When alcohol is consumed in excessive quantities, the resulting high levels of NADH cause metabolic abnormalities, one of which is high levels of fatty acid synthesis. Fatty acid synthesis, also a cytoplasmic process, uses acetyl-CoA as a substrate and NADPH as a reducing agent. Speculate about how a high level of cytoplasmic NADH provides a source of NADPH for fatty acid synthesis.
How many total moles of ATP are created in a cell with an ATP synthase with 8 c subunits for every 28 moles of glucose that is completely oxidized in glycolysis and the Krebs cycle? Assume that NADH is transported by the malate aspartate shuttle.
ADP and inorganic phosphate are provided for oxidative phosphorylation via an: ADP-ATP antiport and a proton-phosphate symport in the inner mitochondrial membrane. ADP-ATP antiport and a proton-phosphate symport in the outer mitochondrial membrane. O ADP-ATP antiport in the inner mitochondrial membrane and a phosphate uniport in the mitochondrial intermembrane space. ADP-phosphate symport in the inner mitochondrial membrane.

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