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The intense acidification observed in the stomach lumen is energetically driven by O a parietal cell isozyme of carbonic anhydrase O an H+ ATPase the pumps H+ from the parietal cell into the lumen O the large gradient of Cl- ion in the plasma that allows movement of H+ into the lumen O an OH-transporting ATPase that removes this ion from the lumen, causing a drop in pH

The intense acidification observed in the stomach lumen is energetically driven by O a parietal cell isozyme of carbonic anhydrase O an H+ ATPase the pumps H+ from the parietal cell into the lumen O the large gradient of Cl- ion in the plasma that allows movement of H+ into the lumen O an OH-transporting ATPase that removes this ion from the lumen, causing a drop in pH

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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### The Intense Acidification in the Stomach Lumen: An Energetic Perspective **Question:** The intense acidification observed in the stomach lumen is energetically driven by: **Options:** 1. A parietal cell isozyme of carbonic anhydrase 2. An H+ ATPase that pumps H+ from the parietal cell into the lumen 3. The large gradient of Cl- ion in the plasma that allows movement of H+ into the lumen 4. An OH- transporting ATPase that removes this ion from the lumen, causing a drop in pH **Explanation:** This question explores the mechanism behind the acidification process in the stomach lumen. Each of the options provided points to a different biological process or enzyme that could be responsible for this phenomenon. Understanding the correct option involves a deep dive into gastric physiology and cellular mechanisms associated with ion transport. **Educational Note:** - **Parietal cells** are crucial in producing hydrochloric acid (HCl) in the stomach. - **Carbonic anhydrase** is an enzyme that helps convert carbon dioxide and water to bicarbonate and protons (H+). - **H+ ATPase (Proton pump)**: This enzyme is specifically responsible for actively transporting hydrogen ions (H+) from parietal cells into the stomach lumen, crucial for the acidification process. - **Chloride (Cl-) gradient**: Plays a role in balancing ionic charges but is not the driving force of H+ movement. - **OH- transporting ATPase**: Not typically involved in the primary process of stomach acidification. **Correct Answer:** The process is primarily driven by the **H+ ATPase** that pumps H+ from the parietal cells into the lumen, making Option 2 the correct answer. This proton pump is essential for creating the highly acidic environment necessary for digestive processes in the stomach.
Transcribed Image Text:### The Intense Acidification in the Stomach Lumen: An Energetic Perspective **Question:** The intense acidification observed in the stomach lumen is energetically driven by: **Options:** 1. A parietal cell isozyme of carbonic anhydrase 2. An H+ ATPase that pumps H+ from the parietal cell into the lumen 3. The large gradient of Cl- ion in the plasma that allows movement of H+ into the lumen 4. An OH- transporting ATPase that removes this ion from the lumen, causing a drop in pH **Explanation:** This question explores the mechanism behind the acidification process in the stomach lumen. Each of the options provided points to a different biological process or enzyme that could be responsible for this phenomenon. Understanding the correct option involves a deep dive into gastric physiology and cellular mechanisms associated with ion transport. **Educational Note:** - **Parietal cells** are crucial in producing hydrochloric acid (HCl) in the stomach. - **Carbonic anhydrase** is an enzyme that helps convert carbon dioxide and water to bicarbonate and protons (H+). - **H+ ATPase (Proton pump)**: This enzyme is specifically responsible for actively transporting hydrogen ions (H+) from parietal cells into the stomach lumen, crucial for the acidification process. - **Chloride (Cl-) gradient**: Plays a role in balancing ionic charges but is not the driving force of H+ movement. - **OH- transporting ATPase**: Not typically involved in the primary process of stomach acidification. **Correct Answer:** The process is primarily driven by the **H+ ATPase** that pumps H+ from the parietal cells into the lumen, making Option 2 the correct answer. This proton pump is essential for creating the highly acidic environment necessary for digestive processes in the stomach.
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