The gene Igf2 for the insulin-like growth factor (IGF) promotes growth hormone production and cell proliferation, and is maternally imprited. The IGF receptor gene Igf2r counters the effects of the Igf2 gene and is paternally imprinted. In knockout experiments with mice, which combination of manipulated genes will result in mice that will grow to normal size? (a) The maternally derived Igf2r and paternally derived igf2 are both normally expressed. (b) The maternally derived Igf2r and paternally derived igf2 are both
The gene Igf2 for the insulin-like growth factor (IGF) promotes growth hormone production and cell proliferation, and is maternally imprited. The IGF receptor gene Igf2r counters the effects of the Igf2 gene and is paternally imprinted. In knockout experiments with mice, which combination of manipulated genes will result in mice that will grow to normal size?
(a) The maternally derived Igf2r and paternally derived igf2 are both normally expressed.
(b) The maternally derived Igf2r and paternally derived igf2 are both deleted.
(c) The maternally derived Igf2r is normally expressed but the paternally derived Igf2 is deleted.
(d) The paternally derived Igf2 is normally expressed but the maternally derived Igf2r is deleted.
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