. The following diagram shows the biosynthesis of B12 coenzymes, starting with the vitamin. DMB is dimethylbenzimidazole. (a) What one additional substrate or cofactor is required by enzyme B? (b) Genetic deficiency in animals of enzyme C would result in exces- sive urinary excretion of what compound? CH3 OH OH -DMB (B 2e он он OH OH Ço -DMB A - DMB Adenine АТР Ço* Pi+ PP -DMB (c) Some forms of the condition described in (b) can be successfully treated by injection of rather massive doses of vitamin B12. What kind of genetic alteration in the enzyme would be consistent with this result? (d) Genetic deficiency in animals of enzyme B will result in excessive urinary excretion of what amino acid?
. The following diagram shows the biosynthesis of B12 coenzymes, starting with the vitamin. DMB is dimethylbenzimidazole. (a) What one additional substrate or cofactor is required by enzyme B? (b) Genetic deficiency in animals of enzyme C would result in exces- sive urinary excretion of what compound? CH3 OH OH -DMB (B 2e он он OH OH Ço -DMB A - DMB Adenine АТР Ço* Pi+ PP -DMB (c) Some forms of the condition described in (b) can be successfully treated by injection of rather massive doses of vitamin B12. What kind of genetic alteration in the enzyme would be consistent with this result? (d) Genetic deficiency in animals of enzyme B will result in excessive urinary excretion of what amino acid?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
![. The following diagram shows the biosynthesis of B12 coenzymes,
starting with the vitamin. DMB is dimethylbenzimidazole.
(a) What one additional substrate or cofactor is required by enzyme B?
(b) Genetic deficiency in animals of enzyme C would result in exces-
sive urinary excretion of what compound?](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F7aeb1dce-80d4-4a4c-9268-002e3a4aa85f%2F5f716e5c-d0af-48c7-8d86-e69814da3f09%2Ftvag73m_processed.png&w=3840&q=75)
Transcribed Image Text:. The following diagram shows the biosynthesis of B12 coenzymes,
starting with the vitamin. DMB is dimethylbenzimidazole.
(a) What one additional substrate or cofactor is required by enzyme B?
(b) Genetic deficiency in animals of enzyme C would result in exces-
sive urinary excretion of what compound?
![CH3
OH
OH
-DMB
(B
2e
он он
OH OH
Ço
-DMB
A
- DMB
Adenine
АТР
Ço*
Pi+ PP
-DMB
(c) Some forms of the condition described in (b) can be successfully
treated by injection of rather massive doses of vitamin B12. What kind
of genetic alteration in the enzyme would be consistent with this result?
(d) Genetic deficiency in animals of enzyme B will result in excessive
urinary excretion of what amino acid?](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F7aeb1dce-80d4-4a4c-9268-002e3a4aa85f%2F5f716e5c-d0af-48c7-8d86-e69814da3f09%2Fbughdfq_processed.png&w=3840&q=75)
Transcribed Image Text:CH3
OH
OH
-DMB
(B
2e
он он
OH OH
Ço
-DMB
A
- DMB
Adenine
АТР
Ço*
Pi+ PP
-DMB
(c) Some forms of the condition described in (b) can be successfully
treated by injection of rather massive doses of vitamin B12. What kind
of genetic alteration in the enzyme would be consistent with this result?
(d) Genetic deficiency in animals of enzyme B will result in excessive
urinary excretion of what amino acid?
Expert Solution
![](/static/compass_v2/shared-icons/check-mark.png)
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
Step by step
Solved in 4 steps
![Blurred answer](/static/compass_v2/solution-images/blurred-answer.jpg)
Recommended textbooks for you
![Biochemistry](https://www.bartleby.com/isbn_cover_images/9781319114671/9781319114671_smallCoverImage.jpg)
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
![Lehninger Principles of Biochemistry](https://www.bartleby.com/isbn_cover_images/9781464126116/9781464126116_smallCoverImage.gif)
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
![Fundamentals of Biochemistry: Life at the Molecul…](https://www.bartleby.com/isbn_cover_images/9781118918401/9781118918401_smallCoverImage.gif)
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
![Biochemistry](https://www.bartleby.com/isbn_cover_images/9781319114671/9781319114671_smallCoverImage.jpg)
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
![Lehninger Principles of Biochemistry](https://www.bartleby.com/isbn_cover_images/9781464126116/9781464126116_smallCoverImage.gif)
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
![Fundamentals of Biochemistry: Life at the Molecul…](https://www.bartleby.com/isbn_cover_images/9781118918401/9781118918401_smallCoverImage.gif)
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
![Biochemistry](https://www.bartleby.com/isbn_cover_images/9781305961135/9781305961135_smallCoverImage.gif)
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
![Biochemistry](https://www.bartleby.com/isbn_cover_images/9781305577206/9781305577206_smallCoverImage.gif)
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
![Fundamentals of General, Organic, and Biological …](https://www.bartleby.com/isbn_cover_images/9780134015187/9780134015187_smallCoverImage.gif)
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON