The drug AZT was the first drug that seemed effective in delaying the onset of AIIDS in people infected with HIV. Evidence for AZT's effectiveness came from a large randomized comparative experiment. The subjects were 1300 HIV-positive volunteers who had not yet developed AlIDS. The double-blind study assigned 435 of the subjects at random to take 500 milligrams of AZT each day and another 435 to take a placebo. At the end of the study, 38 of the placebo subjects and 17 of the AZT subjects had developed AlIDS. (a) Calculate and interpret the odds ratio, OR, and the relative risk, RR, for the AZT group compared with the placebo group. (Enter your answers rounded to four decimal places.) RR = OR =
The drug AZT was the first drug that seemed effective in delaying the onset of AIIDS in people infected with HIV. Evidence for AZT's effectiveness came from a large randomized comparative experiment. The subjects were 1300 HIV-positive volunteers who had not yet developed AlIDS. The double-blind study assigned 435 of the subjects at random to take 500 milligrams of AZT each day and another 435 to take a placebo. At the end of the study, 38 of the placebo subjects and 17 of the AZT subjects had developed AlIDS. (a) Calculate and interpret the odds ratio, OR, and the relative risk, RR, for the AZT group compared with the placebo group. (Enter your answers rounded to four decimal places.) RR = OR =
MATLAB: An Introduction with Applications
6th Edition
ISBN:9781119256830
Author:Amos Gilat
Publisher:Amos Gilat
Chapter1: Starting With Matlab
Section: Chapter Questions
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Transcribed Image Text:The drug AZT was the first drug that seemed effective in delaying the onset of AIIDS in people infected with HIV. Evidence
for AZT's effectiveness came from a large randomized comparative experiment. The subjects were 1300 HIV-positive
volunteers who had not yet developed AIIDS.
The double-blind study assigned 435 of the subjects at random to take 500 milligrams of AZT each day and another 435 to
take a placebo. At the end of the study, 38 of the placebo subjects and 17 of the AZT subjects had developed AIDS.
(a) Calculate and interpret the odds ratio, OR, and the relative risk, RR, for the AZT group compared with the placebo
group. (Enter your answers rounded to four decimal places.)
RR =
OR =
How do the values for OR and RR compare?
O The OR value is much larger than the RR value which must imply the risk of getting AIDS while not using AZT is
much higher. Both values are very easy to interpret since they are quite intuitive.
O The OR value is somewhat similar to the RR value but is more challenging to interpret because odds are less intuitive.
O The OR value is very different from the RR value, neither value is very challenging to interpret since they are both
simple ratios.
The OR value is much smaller than the RR value which must imply the risk of getting AIDS while not using AZT is
much higher. Both values are very hard to interpret since they are not very intuitive.
(b) Calculate the absolute and the relative risk reduction for AIIDS onset. (Enter your answers rounded to four decimal places.)
ARR =
RRR =
(c) Calculate the number needed to treat with AZT compared with a placebo to prevent the onset of AIDS in 1 patient. (Enter
your answer as a whole number.)
NNT =
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