The compound tetraethylammonium (TEA) blocks the voltage-gated changes in potassium permeability that occurs during an action potential. After administration of TEA, what changes would you expect in the action potential?
The compound tetraethylammonium (TEA) blocks the voltage-gated changes in potassium permeability that occurs during an action potential. After administration of TEA, what changes would you expect in the action potential?
Action potentials are known to be the source of neuronal transmission, in the form of electrical signals. The cell membrane has a resting membrane potential of -70 mV with negative towards the inner face of the membrane. The mechanism of generation of an action potential is regulated by ionic channels via their selective permeability of ions and is also determined by the concentration gradient of ions present at a specific point of time (ions present outside and inside of the cell). Small molecules like Tetraethylammonium (TEA) has been used to study the properties of the ion channels. TEA is a potassium-selective ion channel blocker.
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