Describe the neurotransmitters shown in Section 11.14 in the selected neurotransmitters table. Give examples of how they might occur in the body.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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Describe the neurotransmitters shown in Section 11.14 in the selected neurotransmitters table. Give examples of how they might occur in the body.

Selected Neurotransmitters
Neurotransmitter
Chemical Structure
Mechanism of Action Location
Comments
Acetylcholine (ACh)
CH,
Primarily direct, through CNS: Synapses throughout brain
CH,-N -CH,-CH,-o-c-CH, binding to chemically
CH,
and spinal cord
PNS: Neuromuscular junctions,
neuroglandular junctions, and
synapses in autonomic ganglia
Widespread in CNS and
PNS; best known and
most studied of the
gated ion channels
neurotransmitters
он
Involved in attention and
consciousness, control of
body temperature, and
regulation of pituitary gland
secretion
Norepinephrine (NE)
Indirect, through
G proteins and second
CNS: Cerebral cortex,
hypothalamus, brainstem,
cerebellum, and spinal cord
PNS: Most neuromuscular and
neuroglandular junctions of
sympathetic division of ANS
NH,-CH,-CH-
он
messengers
OH
он
Epinephrine (E)
CH,-NH-CH,-CH-
Indirect: G proteins and
OH second messengers
CNS: Thalamus, hypothalamus,
midbrain, and spinal cord
Generally excitatory effect
along autonomic pathways
HO,
OH Primarily indirect:
G proteins and second
messengers
Serotonin
CNS: Hypothalamus, limbic
Important in emotional
states, moods, and body
temperature; several illicit
hallucinogenic drugs, such
as Ecstasy, target serotonin
receptors
NH,-CH,-CH,-
system, cerebellum, spinal cord,
and retina
CNS: Cerebral cortex and
Important in memory and
learning; most important
excitatory neurotransmitter
in the brain
Glutamate
c-CH-CH,-CH,-C
HƠ
Indirect: G proteins and
second messengers
Direct: opens calcium/
sodium ion channels
brainstem
он
NH,
Gamma-
Direct or indirect
CNS: Cerebral cortex, cerebellum, Direct inhibitory effects:
opens Cl channels; indirect
effects: opens K channels
and blocks entry of Ca2+
NH,-CH,-CH,-CH,-c
aminobutyric
acid (GABA)
(G proteins), depending
interneurons throughout brain
and spinal cord
OH
on type of receptor
Transcribed Image Text:Selected Neurotransmitters Neurotransmitter Chemical Structure Mechanism of Action Location Comments Acetylcholine (ACh) CH, Primarily direct, through CNS: Synapses throughout brain CH,-N -CH,-CH,-o-c-CH, binding to chemically CH, and spinal cord PNS: Neuromuscular junctions, neuroglandular junctions, and synapses in autonomic ganglia Widespread in CNS and PNS; best known and most studied of the gated ion channels neurotransmitters он Involved in attention and consciousness, control of body temperature, and regulation of pituitary gland secretion Norepinephrine (NE) Indirect, through G proteins and second CNS: Cerebral cortex, hypothalamus, brainstem, cerebellum, and spinal cord PNS: Most neuromuscular and neuroglandular junctions of sympathetic division of ANS NH,-CH,-CH- он messengers OH он Epinephrine (E) CH,-NH-CH,-CH- Indirect: G proteins and OH second messengers CNS: Thalamus, hypothalamus, midbrain, and spinal cord Generally excitatory effect along autonomic pathways HO, OH Primarily indirect: G proteins and second messengers Serotonin CNS: Hypothalamus, limbic Important in emotional states, moods, and body temperature; several illicit hallucinogenic drugs, such as Ecstasy, target serotonin receptors NH,-CH,-CH,- system, cerebellum, spinal cord, and retina CNS: Cerebral cortex and Important in memory and learning; most important excitatory neurotransmitter in the brain Glutamate c-CH-CH,-CH,-C HƠ Indirect: G proteins and second messengers Direct: opens calcium/ sodium ion channels brainstem он NH, Gamma- Direct or indirect CNS: Cerebral cortex, cerebellum, Direct inhibitory effects: opens Cl channels; indirect effects: opens K channels and blocks entry of Ca2+ NH,-CH,-CH,-CH,-c aminobutyric acid (GABA) (G proteins), depending interneurons throughout brain and spinal cord OH on type of receptor
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