Synaptic fatigue is due to : -a- decreased synthesis of neurotransmittersb- inability to release neurotransmitters by exocytosisc- failure of action potentials to open voltage-gated Ca ++ channels in presynaptic terminald- imbalance in between rates of synthesis and release of neurotransmitters
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Synaptic fatigue is due to : -
a- decreased synthesis of neurotransmitters
b- inability to release neurotransmitters by exocytosis
c- failure of action potentials to open voltage-gated Ca ++ channels in
presynaptic terminal
d- imbalance in between rates of synthesis and release of neurotransmitters
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- Assume presynaptic excitatory neuron A terminates on a postsynaptic cell near the axon hillock and presynaptic excitatory neuron B terminates on the same postsynaptic cell on a dendrite located on the side of the cell body opposite the axon hillock. Explain why rapid firing of presynaptic neuron A could bring the postsynaptic neuron to threshold through temporal summation, thus initiating an action potential, whereas firing of presynaptic neuron B at the same frequency and the same magnitude of EPSPs may not bring the postsynaptic neuron to threshold.Synaptic transmission depends upon :- a-direct transmission of impulses from the presynaptic neuron to the postsynaptic neuronb- diffusion of neurotransmitters from synaptic knobs into the soma and dendrites of postsynaptic neuronsc- presence of voltage-gated Ca ++ channels in membrane of synaptic knobsd- presence of voltage-gated Ca ++ channels in the subsynaptic membraneSynaptic transmission is inhibited by all the following, except :-a- oxygen lackb- alkalosisc- acidosisd- prolonged activity of synapse
- Long-term potentiation of synaptic transmission :-a- is involved in pain control systemb- is caused by increased Ca ++ concentration in presynaptic neuronsc- results from fast repetitive stimulation of synapsed- is associated with decreased Ca ++ concentration in postsynaptic neuronsArrange the events that occur during synaptic transmission. Use letters A-F to denote the correct sequence. Use the diagram on the right as a clue. Example: SENDING NEURON B 1. lon channel opens Synepto SYNAPSE 1. lon channel opens 2. Neurotransmitter is released into synaptic cleft SYNAPTIC CLEFT RECEVING HEURC4 Neurotransmitter 3. Vesicle fuses with plasma membrane Jon chennels Neurotransmtter Reseptor deurotranemitter brohen down and sa sd 4. Neurotransmitter binds to receptor BOns 前 命 5. Action potential arrives 6. lon channel closes the obeicos in the bo y belo M (A nPost-tetanic Potentiation in synapses :-a- is due to increased Ca ++ concentration in postsynaptic neuronsb- is due to increased Ca ++ influx into presynaptic neuronsc- results from slow prolonged stimulation of synapsed- causes fatigue of the synapse
- If a post synaptic neuron is stimulated to threshold by spatial summation this implies that the post synaptic cell has a lower than normal threshold the postsynaptic cell has many synapses with many presynaptic neurons the post synaptic cell is getting stimulated many times during a short period of time by a single presynaptic neuron the post synaptic cell is slow to repolarizeWhen a postsynaptic neuron is adequately stimulated, action potentials develop at the initial segment of the axon because :-a- it contains many voltage-gated Na + channelsb- it contains the highest concentration of ligand-gated cation channelsc- it contains many voltage-gated Ca ++ channelsd- it is more sensitive to the direct stimulant effect of neurotransmittersSynaptic terminal Neurotransmitter SENDING NEURON Vesicle Calcium channel Receptor for neurotransmitter RECEIVING NEURON Synaptic cleft
- If action potential propagation from one neuron to another neuron requires ACh release, what event at the synaptic cleft explains the need for action potentials to arrive at a high rate before the post-synaptic membrane achieves threshold? the lack of sodium voltage gated channels on the post-synaptic membrane O the rapid breakdown of ACh by ACHE at the synaptic cleft the slow release of ACh by the synaptic vessicles the slow movement of sodium through chemical gates Previous Next MacBook AirSynaptic terminal Neurotransmitter Vesicle Calcium channel Receptor for neurotransmitter Synaptic cleft SENDING NEURON RECEIVING NEURON 000Which of the following are the likely explanations for the failure of a postsynaptic neuron to trigger an action potential? Select all that apply. The EPSPs are neutralized by the neurotransmitter The summation of IPSPs and EPSPs is insufficient to depolarize the cell to threshold The synapses generating the EPSPs are too close to the axon hillock The synapses generating the EPSPs are too far from the axon hillock
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