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Suppose there is a glycolytic-like pathway carried out by an alien species that uses analogous enyzme mechanisms to convert an 8-carbon sugar (① see structure below) to two 4 carbon fragments and then to a pyruvate analog.  Draw the mechanism for the conversion of 8-carbon bisphosphate (compound ④ below) to the two 4 carbon fragments (compounds ⑤ and ⑥) using the mechanism of fructose-1,6-bisphosphate aldolase (Type I) as your model.  You need to include the steps for the formation of the covalent intermediate between the enzyme and the substrate.

Suppose there is a glycolytic-like pathway carried out by an alien species that uses analogous enyzme mechanisms to convert an 8-carbon sugar (① see structure below) to two 4 carbon fragments and then to a pyruvate analog.  Draw the mechanism for the conversion of 8-carbon bisphosphate (compound ④ below) to the two 4 carbon fragments (compounds ⑤ and ⑥) using the mechanism of fructose-1,6-bisphosphate aldolase (Type I) as your model.  You need to include the steps for the formation of the covalent intermediate between the enzyme and the substrate.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Suppose there is a glycolytic-like pathway carried out by an alien species that uses analogous enyzme mechanisms to convert an 8-carbon sugar (① see structure below) to two 4 carbon fragments and then to a pyruvate analog.  Draw the mechanism for the conversion of 8-carbon bisphosphate (compound ④ below) to the two 4 carbon fragments (compounds ⑤ and ⑥) using the mechanism of fructose-1,6-bisphosphate aldolase (Type I) as your model.  You need to include the steps for the formation of the covalent intermediate between the enzyme and the substrate.

HO HO- CH₂OH -OH -OH OH CH₂OH НО НО- CH₂OH CH₂OH CH₂OPO3²- -OH -OH -OH -OH CH₂OPO3²- НО НО- CH₂OH -OH -OH -ОН CH₂OPO3²- CHO -ОН -OH CH₂OPO3²- HO HO CH₂OPO3²- -ОН -OH -OH CH₂OPO3²-
Transcribed Image Text:HO HO- CH₂OH -OH -OH OH CH₂OH НО НО- CH₂OH CH₂OH CH₂OPO3²- -OH -OH -OH -OH CH₂OPO3²- НО НО- CH₂OH -OH -OH -ОН CH₂OPO3²- CHO -ОН -OH CH₂OPO3²- HO HO CH₂OPO3²- -ОН -OH -OH CH₂OPO3²-
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