Suppose there is a glycolytic-like pathway carried out by an alien species that uses analogous enyzme mechanisms to convert an 8-carbon sugar (① see structure below) to two 4 carbon fragments and then to a pyruvate analog.  Draw the mechanism for the conversion of 8-carbon bisphosphate (compound ④ below) to the two 4 carbon fragments (compounds ⑤ and ⑥) using the mechanism of fructose-1,6-bisphosphate aldolase (Type I) as your model.  You need to include the steps for the formation of the covalent intermediate between the enzyme and the substrate.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Suppose there is a glycolytic-like pathway carried out by an alien species that uses analogous enyzme mechanisms to convert an 8-carbon sugar (① see structure below) to two 4 carbon fragments and then to a pyruvate analog.  Draw the mechanism for the conversion of 8-carbon bisphosphate (compound ④ below) to the two 4 carbon fragments (compounds ⑤ and ⑥) using the mechanism of fructose-1,6-bisphosphate aldolase (Type I) as your model.  You need to include the steps for the formation of the covalent intermediate between the enzyme and the substrate.

HO
HO-
CH₂OH
-OH
-OH
OH
CH₂OH
НО
НО-
CH₂OH
CH₂OH
CH₂OPO3²-
-OH
-OH
-OH
-OH
CH₂OPO3²-
НО
НО-
CH₂OH
-OH
-OH
-ОН
CH₂OPO3²-
CHO
-ОН
-OH
CH₂OPO3²-
HO
HO
CH₂OPO3²-
-ОН
-OH
-OH
CH₂OPO3²-
Transcribed Image Text:HO HO- CH₂OH -OH -OH OH CH₂OH НО НО- CH₂OH CH₂OH CH₂OPO3²- -OH -OH -OH -OH CH₂OPO3²- НО НО- CH₂OH -OH -OH -ОН CH₂OPO3²- CHO -ОН -OH CH₂OPO3²- HO HO CH₂OPO3²- -ОН -OH -OH CH₂OPO3²-
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