Suppose there is a glycolytic-like pathway carried out by an alien species that uses analogous enyzme mechanisms to convert an 8-carbon sugar (① see structure below) to two 4 carbon fragments and then to a pyruvate analog. Draw the mechanism for the conversion of 8-carbon bisphosphate (compound ④ below) to the two 4 carbon fragments (compounds ⑤ and ⑥) using the mechanism of fructose-1,6-bisphosphate aldolase (Type I) as your model. You need to include the steps for the formation of the covalent intermediate between the enzyme and the substrate.
Suppose there is a glycolytic-like pathway carried out by an alien species that uses analogous enyzme mechanisms to convert an 8-carbon sugar (① see structure below) to two 4 carbon fragments and then to a pyruvate analog. Draw the mechanism for the conversion of 8-carbon bisphosphate (compound ④ below) to the two 4 carbon fragments (compounds ⑤ and ⑥) using the mechanism of fructose-1,6-bisphosphate aldolase (Type I) as your model. You need to include the steps for the formation of the covalent intermediate between the enzyme and the substrate.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Suppose there is a glycolytic-like pathway carried out by an alien species that uses analogous enyzme mechanisms to convert an 8-carbon sugar (① see structure below) to two 4 carbon fragments and then to a pyruvate analog. Draw the mechanism for the conversion of 8-carbon bisphosphate (compound ④ below) to the two 4 carbon fragments (compounds ⑤ and ⑥) using the mechanism of fructose-1,6-bisphosphate aldolase (Type I) as your model. You need to include the steps for the formation of the covalent intermediate between the enzyme and the substrate.
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