Radioactive uracil can be used to label all of the pyrimidine residues inDNA. Using either names or structures, present pathways for the conversionof uracil to dTTP and to dCTP. For each reaction, show the involvement ofcofactors, and identify sites of allosteric regulation. Similarly, hypoxanthine (HX) can be used to label purine residues. As given above, write reactions showing the conversion of hypoxanthine to dATP and dGTP.
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
Radioactive uracil can be used to label all of the pyrimidine residues in
DNA. Using either names or structures, present pathways for the conversion
of uracil to dTTP and to dCTP. For each reaction, show the involvement of
cofactors, and identify sites of allosteric regulation.
Similarly, hypoxanthine (HX) can be used to label purine residues. As given above, write reactions showing the conversion of hypoxanthine to dATP and dGTP.
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