Question 6 of 19 Proteasomal proteases can be inhibited by compounds such as ixazomib (shown below). How does this compound inhibit protease activity? HO Ixazomib O Uncomptetitively O Competitively O Noncompetitively

Q: Fill in the blanks: Write C if only statement A is correct, Hif only statement B is correct, E if…

A: Uncompetitive inhibition  When an inhibitor binds only to the enzyme and the substrate complex.

Q: Question 4 A series of 6-arylmethylidene penicillin-based sulfone inhibitors (1) were developed as a…

A: In gram-negative bacteria, beta-lactamase provides a resistance mechanism. It has four classes of…

Q: For hemoglobin, when there is an increased concentration of CO2, this will result in a lower P50…

A: ANSWER;- 1)False Explain;- For hemoglobin, there is an increased concentration of CO2, this will…

Q: Why are false-negative results usually more common than false-positive results in biochemical and…

A: A false-positive result is a result which is interpreted as true but it is, in reality, false. The…

Q: 10) Explain how the Km and [VO] of a reaction between a fixed amount of catalase and a gradually…

A: An allosteric inhibitor doesn't competes with the substrate for binding at active site. It binds to…

Q: Question is mentioned in the attached file

A: In the bacteria, Salmonella typhimurium a series of mutations occurs that results in the requirement…

Q: Human xanthine oxidase catalyzes the oxidation of hypoxanthine to xanthine and can furthercatalyze…

A: Human xanthine oxidase is an enzyme that catalyzes the oxidation of hypoxanthine to xanthine and…

Q: Given the active site diagram and reaction mechanism, indicate the mechanism of irreversible…

A: Inhibition is of 2 type; Reversible inhibition and Irreversible inhibition. It is said that the…

Q: 3CLpro is a cysteine protease, which are among the most common proteases in biochemistry, however…

A: The 3 dimensional conformation of a biomolecule is highly specific and vital to its function,…

Q: Treatment of this compound with Phospholipase D leads to and OA triacyl glycerol; inositol…

A: Phospholipase is an enzyme, which is known to hydrolyze phospholipids into lipophilic substances,…

Q: One way of expressing the rate at which an enzyme can catalyze a reaction is to state its turnover…

A: Kcat, or turnover number is the number of substrate molecules converted to product at one active…

Q: You are studying an enzyme that you isolated from cells growing at 25°C in an alkaline environment…

A: Vmax is the reaction rate given at the moment the enzyme is fully saturated by substrate. This…

Q: A histidine side chain is known to play an import-ant role in the catalytic mechanism of an enzyme;…

A: Enzyme activity is the micromoles of substrates converted to products per minute. It is given as the…

Q: An enzvme has an all-important histidine residue in its active site such that substitution with an…

A: Amino acids are the building blocks of proteins, which are essential for the structure and function…

Q: Upon digestion of starch, isomaltose (an isomer of maltose), one of its degradation products, is…

A: Aerobic metabolism is a set of three basic metabolic processes that occur in cells to generate…

Q: The drug troglitazone was used to treat diabetes but was withdrawn from the market when patients who…

A: Parameters such as Km and Vmax are used for comparing enzyme activities. If we know the initial rate…

Q: Since two 19S regulatory subunits and a 20S catalytic unit constitute the 26S proteasome, why is the…

A: A peptide is a short chain of amino acid residues linked together via peptide bonds. A folded…

Q: QUESTION 2 The Michaelis-Menten and the Lineweaver-Burk plots can be used to determine the Km and…

A: Enzymes are biocatalysts that assist in speeding up any biochemical reactions but they do not…

Q: In trimetric G proteins the only function of the bamma y complex is to allow reactivating of the a…

A: G proteins are called the guanine nucleotide proteins that are responsible for switching on and off…

Q: Starting from the situation below, explain the next immediate steps that occur after the agonist…

A: GTP stands for Guanosine Triphosphate. It is a nucleotide which is a molecule composed of a…

Q: “Caspase” describes the catalytic activity of this enzyme. What amino acyl residue participates in…

A: Caspases are enzymes which mainly take part in programmed cell death. A part from that they also…

Q: The hormone cortisol causes activation of pathways that under normal conditions 4. are not active at…

A: Gluconeogenesis is the synthesis of glucose residues from non-carbohydrate sources such as pyruvate,…

Q: The peptide hormone glucagon tends to elevated in between meals. Among the effects that glucagon has…

A: Eukaryotic elongation Factor 2 (eEF2) mediates translocation of peptidyl-tRNA from A-site to P site…

Q: Based on the data provided, are they going to authorize it as a medication or not? Explain?

A: Xanthine oxidase is responsible for the production of ROS (reactive oxygen species). It is involved…

Q: What step ends the first-half of the chymotrypsin mechanism? Attack of water on the acyl-enzyme…

A: Chymotrypsin is a proteolytic enzyme secreted by the pancreases  in the small intestine.

Q: From the complete oxidation of glucose (glucose  →  6CO2), how many total nucleotide triphosphates…

A: Glucose metabolism's major pathway is glycolysis. Which take place in both aerobic…

Q: In N-linked glycoproteins, the sugar molecule is usually bound to Thr Asn Asp Ser

A: N-linked glycoproteins are proteins that have sugar molecules specifically oligosaccharides attached…

Q: Suppose that an aspartic acid (aspartate) residue in the active site of an enzyme was mutated to…

A: Introduction: Amino acids are biomolecules that comprise two functional groups; amino (-NH2) and…

Q: Human xanthine oxidase catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze…

A: Human xanthine oxidase catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze…

Q: n. The diagram below shows the kinetic plot of collagenase with varied substrate concentration.…

A: enzyme activity is defined as the total concentration of substrate converted into product per unit…

Q: Fill in the blanks: Write Cif only statement A is correct, Hif only statement B is correct, E if…

A: M is the correct answer as both the statements are correct. In enzyme catalyzed reactions, substrate…

Q: Human xanthine oxidase catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze…

A: Human xanthine oxidase catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze…

Q: Graph #4 Substrate concentration #4, the solid line represents the rate of an enzyme reaction with…

A: An inhibitor is any molecule which binds to the enzyme and decrease its catalytic efficiency.