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Question 2. An enzyme was found to convert Acetyl-coA to an acetyl-cysteine intermediate of the enzyme. The structure of COA is: H H НО СН, HS — СH2— СH, — N—С— СН, — СН;—N—С Ċ–Ċ–CH2-0 0-P-0-CH2 Adenine H CH5 H H H H Phosphopantetheine group of coenzyme A 2-O,PO OH Draw a plausible chemical mechanism. Where is the acetyl-group in acetyl-coA? What is the reactive group of the protein? The reaction is enhanced at higher pH. How is this consistent with your mechanism? Is covalent catalysis involved? www

Question 2. An enzyme was found to convert Acetyl-coA to an acetyl-cysteine intermediate of the enzyme. The structure of COA is: H H НО СН, HS — СH2— СH, — N—С— СН, — СН;—N—С Ċ–Ċ–CH2-0 0-P-0-CH2 Adenine H CH5 H H H H Phosphopantetheine group of coenzyme A 2-O,PO OH Draw a plausible chemical mechanism. Where is the acetyl-group in acetyl-coA? What is the reactive group of the protein? The reaction is enhanced at higher pH. How is this consistent with your mechanism? Is covalent catalysis involved? www

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question 2. An enzyme was found to convert Acetyl-coA to an acetyl-cysteine intermediate of the enzyme. The structure of cOA is: H H НО СН; HS — СH2— СH2 — N—C—CH,— CH2—N- С—С—С—CH;—0—Р- 0–CH2 Adenine н CH H H H Phosphopantetheine group of coenzyme A 2-O3PO ОН Draw a plausible chemical mechanism. Where is the acetyl-group in acetyl-coA? What is the reactive group of the protein? The reaction is enhanced at higher pH. How is this consistent with your mechanism? Is covalent catalysis involved?
Transcribed Image Text:Question 2. An enzyme was found to convert Acetyl-coA to an acetyl-cysteine intermediate of the enzyme. The structure of cOA is: H H НО СН; HS — СH2— СH2 — N—C—CH,— CH2—N- С—С—С—CH;—0—Р- 0–CH2 Adenine н CH H H H Phosphopantetheine group of coenzyme A 2-O3PO ОН Draw a plausible chemical mechanism. Where is the acetyl-group in acetyl-coA? What is the reactive group of the protein? The reaction is enhanced at higher pH. How is this consistent with your mechanism? Is covalent catalysis involved?
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