17. Omeprazole is a bioprecursor prodrug that is activated by protonation to give active metabolite that inhibits H",K-ATPase covalently. By using chemical equations show activation of Omeprazole and its reaction to inhibit the H",K"-ATPase. CH3 H3C HN N. Omeprazole OCH3

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17. Omeprazole is a bioprecursor prodrug that is activated by protonation to give active
metabolite that inhibits H¨,K*-ATPase covalently. By using chemical equations show
activation of Omeprazole and its reaction to inhibit the H*,K*-ATPase.
CH3
H3CO.
s=0
H3C
HNN
Omeprazole
OCH3
18. The following compound is an open-chain prodrug of benzodiazepines which undergo N-
dealkylation to triazolam. Using chemical equations show transformation of this prodrug
to triazolam.
H3C
H3C
CH3
CH3
triazolam
open-chain prodrug
of triazolam
Transcribed Image Text:17. Omeprazole is a bioprecursor prodrug that is activated by protonation to give active metabolite that inhibits H¨,K*-ATPase covalently. By using chemical equations show activation of Omeprazole and its reaction to inhibit the H*,K*-ATPase. CH3 H3CO. s=0 H3C HNN Omeprazole OCH3 18. The following compound is an open-chain prodrug of benzodiazepines which undergo N- dealkylation to triazolam. Using chemical equations show transformation of this prodrug to triazolam. H3C H3C CH3 CH3 triazolam open-chain prodrug of triazolam
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