Question 3. The Lyme disease spirochete, Borrelia burgdorferi, abundantly produces outer surface lipoprotein A (OspA) in the tick vector but downregulates OspA in mammals in order to evade the immune system and maintain its natural enzootic cycle. The protein BosR is thought to regulate OspA. Below is a protein gel from the spirocete in a tick on the left and from the spirocete in a mammal on the right. From this gel, how is BosR regulating the expression of OspA? Please explain your answer. KD 37- 20- 20- 250- 75- 50- 37- 25- 20- 15- - FlaB A-BosR -OspC -OspA

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question 3. The Lyme disease spirochete, Borrelia burgdorferi, abundantly produces outer
surface lipoprotein A (OspA) in the tick vector but downregulates OspA in mammals in order to
evade the immune system and maintain its natural enzootic cycle. The protein BosR is thought to
regulate OspA. Below is a protein gel from the spirocete in a tick on the left and from the
spirocete in a mammal on the right. From this gel, how is BosR regulating the expression of
OspA? Please explain your answer.
KD
37 -
20-
20-
250-
75-
50-
37-
25-
20-
15-
- FlaB
- BosR
- OspC
- OspA
Double-click to show white space
Transcribed Image Text:Question 3. The Lyme disease spirochete, Borrelia burgdorferi, abundantly produces outer surface lipoprotein A (OspA) in the tick vector but downregulates OspA in mammals in order to evade the immune system and maintain its natural enzootic cycle. The protein BosR is thought to regulate OspA. Below is a protein gel from the spirocete in a tick on the left and from the spirocete in a mammal on the right. From this gel, how is BosR regulating the expression of OspA? Please explain your answer. KD 37 - 20- 20- 250- 75- 50- 37- 25- 20- 15- - FlaB - BosR - OspC - OspA Double-click to show white space
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