Q3: For a new mutation arising in the human BRCA1 gene (designated BRCA1-A4), there is a linked allele, RS651118 ~150,000bp away on the same chromosome. Assume recombination rate (r) is 1% for every megabase. After 25 generations, what is the estimated linkage disequilibrium, D, observed between these two alleles? How much has D changed? Use five decimal places in your calculations.
Genetic Recombination
Recombination is crucial to this process because it allows genes to be reassorted into diverse combinations. Genetic recombination is the process of combining genetic components from two different origins into a single unit. In prokaryotes, genetic recombination takes place by the unilateral transfer of deoxyribonucleic acid. It includes transduction, transformation, and conjugation. The genetic exchange occurring between homologous deoxyribonucleic acid sequences (DNA) from two different sources is termed general recombination. For this to happen, an identical sequence of the two recombining molecules is required. The process of genetic exchange which occurs in eukaryotes during sexual reproduction such as meiosis is an example of this type of genetic recombination.
Microbial Genetics
Genes are the functional units of heredity. They transfer characteristic information from parents to the offspring.
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