Mutations/deficiencies in protein components of the ECM, CAMS, and cell junctions are involved in the expression ofsome human diseases. List and describe these pathologies in the table below. An example is given in the fırst row.Name of diseaseSymptomsMolecular Basis of DiseaseSevere vitamin C deficiency is caused by ascorbicacids' role in collagen synthesis. Vitamin C allowsAnemia, debility, exhaustion, spontaneous hydroxylation and crosslinking of pro-collagenbleeding, pain in the limbs, and especially catalyzed by lysyl hydroxylase. Lack of vitamin Cdecreases transcription of pro-collagen. Additionally,a lack of ascorbic acid leads to epigenetic DNAhypermethylation and inhibits the transcription ofvarious types of collagen found in skin, blood vessels,the legs, swelling in some parts of thebody, and sometimes ulceration of thegums and loss of teethScurvyand tissue.12354.

Mutation :- Mutation is alteration in nucleotide sequence of genome either it is virus or any…

Answered: pxylation and cros yzed by lysyl hydr-…

Phlebotomy Essentials

6th Edition

ISBN:9781451194524

Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)

Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)

Chapter1: Phlebotomy: Past And Present And The Healthcare Setting

Section: Chapter Questions

Problem 1SRQ

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18
normal misfolded amyloid fibril Figure 3.15A The accompanying figure shows the misfolding of the PrPC protein that occurs in varlant Creutzfeldt-Jakob disease (VCJD). The misfolding affects the structure of the normal protein.
Why ammonium chloride an inhibitor for lysosome?
In N-linked glycoproteins, the sugar molecule is usually bound to Thr Asn Asp Ser
aestion How does myoglobin minimize oxidation of the Fe(II) when the heme binds to oxygen? Select one: a. the distal His E7 forms a hydrogen bond to the bound molecular oxygen O b. the oxygen binding site is buried in the hydrophobic core away from water O c. the proximal His F8 forms a coordinate bond to Fe(II), which inhibits oxidation O d. nonpolar interactions with residues Val E11 and Phe CD1 limit oxidation by oxygen Oe. the heme shifts to a planar structure that traps iron in a +2 oxidation state Clear my choice
Important roles and functions of Microtubule-Associated Proteins (MAPs) *** for increase in stability and for the promotion of stability? to increase binding capacity of the motor proteins to associate the subunits with the corresponding motor proteins for the phosphorylation of the plus ends of the microtubule
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Toxin pertussis The a subunit of Gi is ribosylated by ADP. How do you anticipate this poison affecting blood pressure?
Nucleic Acids Convey polypeptide c' minal directi This ques similar to t' carboxy-ter- hesis ing synth to direct sis, the Secon yase aft e genetic groups of 44. Why is ATP important to protein function, and how is it used to accomplish this? which st is. The m fatthaei, synthetic able of r ataining r thus mus ucleotid h of mor Cwas the chemis re critir a 1966 ponded han our PROT mine the s tetail sizer
It is not an easy matter to assign particular func-tions to specific components of the basal lamina, sincethe overall structure is a complicated composite materialwith both mechanical and signaling properties. Nidogen,for example, cross-links two central components of thebasal lamina by binding to the laminin γ-1 chain and totype IV collagen. Given such a key role, it was surprisingthat mice with a homozygous knockout of the gene fornidogen-1 were entirely healthy, with no abnormal phe-notype. Similarly, mice homozygous for a knockout of thegene for nidogen-2 also appeared completely normal. Bycontrast, mice that were homozygous for a defined muta-tion in the gene for laminin γ-1, which eliminated just thebinding site for nidogen, died at birth with severe defectsin lung and kidney formation. The mutant portion of thelaminin γ-1 chain is thought to have no other functionthan to bind nidogen, and does not affect laminin struc-ture or its ability to assemble into the basal lamina.…
Posttranslational modification of proteins,where it occurs, and how new proteinsdestined for extracellular use are packagedand released from a cell
Please help ASAP, thank you! "Which statement concerning this salt bridge is TRUE?"

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pxylation and cros yzed by lysyl hydr- aares transcrintion aases