pxylation and cros yzed by lysyl hydr- aares transcrintion aases

Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
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Mutations/deficiencies in protein components of the ECM, CAMS, and cell junctions are involved in the expression of
some human diseases. List and describe these pathologies in the table below. An example is given in the fırst row.
Name of disease
Symptoms
Molecular Basis of Disease
Severe vitamin C deficiency is caused by ascorbic
acids' role in collagen synthesis. Vitamin C allows
Anemia, debility, exhaustion, spontaneous hydroxylation and crosslinking of pro-collagen
bleeding, pain in the limbs, and especially catalyzed by lysyl hydroxylase. Lack of vitamin C
decreases transcription of pro-collagen. Additionally,
a lack of ascorbic acid leads to epigenetic DNA
hypermethylation and inhibits the transcription of
various types of collagen found in skin, blood vessels,
the legs, swelling in some parts of the
body, and sometimes ulceration of the
gums and loss of teeth
Scurvy
and tissue.
1
2
3
5
4.
Transcribed Image Text:Mutations/deficiencies in protein components of the ECM, CAMS, and cell junctions are involved in the expression of some human diseases. List and describe these pathologies in the table below. An example is given in the fırst row. Name of disease Symptoms Molecular Basis of Disease Severe vitamin C deficiency is caused by ascorbic acids' role in collagen synthesis. Vitamin C allows Anemia, debility, exhaustion, spontaneous hydroxylation and crosslinking of pro-collagen bleeding, pain in the limbs, and especially catalyzed by lysyl hydroxylase. Lack of vitamin C decreases transcription of pro-collagen. Additionally, a lack of ascorbic acid leads to epigenetic DNA hypermethylation and inhibits the transcription of various types of collagen found in skin, blood vessels, the legs, swelling in some parts of the body, and sometimes ulceration of the gums and loss of teeth Scurvy and tissue. 1 2 3 5 4.
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