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Questions Not yet answered Flag question Question 5 Not yet Flag question Complete the following statements regarding the Perutz mechanism for oxygen binding by hemoglobin: The Fe(ll) ion of the heme is pulled into the plane of the porphyrin ring in the T-state of hemoglobin. A network of ion pairs and hydrogen bonds at the subunit interface stabilizes the R-state of hemoglobin. Which factor contributes to the Bohr effect on oxygen binding to hemoglobin? Select one: O a O b. c. d. O e oxidation of the heme bound Fe(l) to Fe(ll) upon oxygen binding hydroxyurea disrupts the aß subunit interface and destabilizes the T-state carbonic anhydrase catalyzes the formation of bicarbonate nitric oxide binds to the a subunit and inhibits oxygen binding to the ß subunit binding of 2,3-bisphosphoglycerate stabilizes the T-state of hemoglobin

Questions Not yet answered Flag question Question 5 Not yet Flag question Complete the following statements regarding the Perutz mechanism for oxygen binding by hemoglobin: The Fe(ll) ion of the heme is pulled into the plane of the porphyrin ring in the T-state of hemoglobin. A network of ion pairs and hydrogen bonds at the subunit interface stabilizes the R-state of hemoglobin. Which factor contributes to the Bohr effect on oxygen binding to hemoglobin? Select one: O a O b. c. d. O e oxidation of the heme bound Fe(l) to Fe(ll) upon oxygen binding hydroxyurea disrupts the aß subunit interface and destabilizes the T-state carbonic anhydrase catalyzes the formation of bicarbonate nitric oxide binds to the a subunit and inhibits oxygen binding to the ß subunit binding of 2,3-bisphosphoglycerate stabilizes the T-state of hemoglobin

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question 4 Not yet answered Flag question Question 5 Not yet answered P Flag question Complete the following statements regarding the Perutz mechanism for oxygen binding by hemoglobin: The Fe(ll) ion of the heme is pulled into the plane of the porphyrin ring in the T-state of hemoglobin. A network of ion pairs and hydrogen bonds at the subunit interface stabilizes the R-state of hemoglobin. Which factor contributes to the Bohr effect on oxygen binding to hemoglobin? Select one: O a. oxidation of the heme bound Fe(l) to Fe(lll) upon oxygen binding O b. c. O d. O e. hydroxyurea disrupts the aß subunit interface and destabilizes the T-state carbonic anhydrase catalyzes the formation of bicarbonate nitric oxide binds to the a subunit and inhibits oxygen binding to the ß subunit binding of 2,3-bisphosphoglycerate stabilizes the T-state of hemoglobin
Transcribed Image Text:Question 4 Not yet answered Flag question Question 5 Not yet answered P Flag question Complete the following statements regarding the Perutz mechanism for oxygen binding by hemoglobin: The Fe(ll) ion of the heme is pulled into the plane of the porphyrin ring in the T-state of hemoglobin. A network of ion pairs and hydrogen bonds at the subunit interface stabilizes the R-state of hemoglobin. Which factor contributes to the Bohr effect on oxygen binding to hemoglobin? Select one: O a. oxidation of the heme bound Fe(l) to Fe(lll) upon oxygen binding O b. c. O d. O e. hydroxyurea disrupts the aß subunit interface and destabilizes the T-state carbonic anhydrase catalyzes the formation of bicarbonate nitric oxide binds to the a subunit and inhibits oxygen binding to the ß subunit binding of 2,3-bisphosphoglycerate stabilizes the T-state of hemoglobin
aestion How does myoglobin minimize oxidation of the Fe(II) when the heme binds to oxygen? Select one: a. the distal His E7 forms a hydrogen bond to the bound molecular oxygen O b. the oxygen binding site is buried in the hydrophobic core away from water O c. the proximal His F8 forms a coordinate bond to Fe(II), which inhibits oxidation O d. nonpolar interactions with residues Val E11 and Phe CD1 limit oxidation by oxygen Oe. the heme shifts to a planar structure that traps iron in a +2 oxidation state Clear my choice
Transcribed Image Text:aestion How does myoglobin minimize oxidation of the Fe(II) when the heme binds to oxygen? Select one: a. the distal His E7 forms a hydrogen bond to the bound molecular oxygen O b. the oxygen binding site is buried in the hydrophobic core away from water O c. the proximal His F8 forms a coordinate bond to Fe(II), which inhibits oxidation O d. nonpolar interactions with residues Val E11 and Phe CD1 limit oxidation by oxygen Oe. the heme shifts to a planar structure that traps iron in a +2 oxidation state Clear my choice
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