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- 17. How would you computationally predict the thermodynamic stability of a long, extended RNA helix? Please explain in 1 sentence how structural "favorability" can be predicted1 In term of the sugar identity , what is the difference between DNA and RNA. 2 What nucleobases are used in DNA? What nucleobases are used in RNA. 3 Draw ATP and abbreviate the nucleobase with A. 4 Draw the synthesis of th edinucleotide formed between ATP and GMP. the 5' triphosphate can be abbreviated, but the monophosphate at the reaction centre should be expanded. NOTE- PLEASE DONOT EXPLAIN TOO MUCH GIVE ANSWER IN SHORT TO TH EPOINT PLEASE.a. Suppose that you have the peptide Ala-Gly-Tyr-His-Leu and you treat it with FDNB and then 6M HCl. Draw the structures of all the products that you will have in solution (assume all reactions to go to completion).
- 9. Shown below is a binding pocket for a protein with a ligand bound. The ligand interacts with a serine and a valine side chain. ligand a. Briefly explain, in terms of Ka, the effect of a mutation that replaces the serine residue with a valine residue. b. Briefly explain, in terms of Kd, the effect of a mutation that alters the ligand (as seen below) binding to the original, unmutated, binding site. :0: ligand 21. What are two major similarities between protein synthesis in bacteria and eukaryotes? What aretwo major differences? 2. Is it reasonable to expect that protein degradation can take place at any location in a cell? 3. . In ubiquitination, chaperone can be part of the process. Explain the benefits of using chaperoneand differentiate the uses of chaperone and ubiquitin.10. How many reducing ends are in a molecule of potato amylopectin that contains 500,000 residues with a branch every 250 residues? Explain your answer.
- 52. The precise biochemical mechanisms underlying the rapid shutdown of glycolysis in skeletal muscle upon termination of muscle contraction have remained poorly understood for many decades. It is known that glycolytic flux declines after exercise even though Pi, ADP, and AMP remain high; however, while these adenosine-5'- nucleotides are allosteric activators of phosphofructokinase-1 (PFK-1), this enzyme remains of low ac- tivity despite their presence. The diagrams (A and B) on the right illustrate the increase in the concentrations of glycolytic in- termediates downstream of PFK-1 during exercise for 60 sec followed by the abrupt decline in their concentrations upon ces- sation of muscle contraction. Diagram C shows changes in the concentrations of phosphate metabolites pre- and post-exer- cise. A. Summed concentration of glycolytic intermediates down- stream of PFK-1 (F1,6P2 + DHAP + G3P + GAP + 1,3BPG + 3PG + 2PG + PEP; G3P, glycerol-3-phosphate). B: PFK-1 flux (grey) and the PGK +…21. Answer and explain