Origin of Replication RNA primer 5' 5' femplate strands Leading strand DNA Lagging strand polymerase 3 5' 5' 3' 5 Helicase DNA Okazaki fragment DNA RNA ligase palymerase primer Figure 9.10 A replication fork is formed by the opening of the origin of replication, and helicase separates the DNA strands. An RNA primer is synthesized, and is elongated by the DNA polymerase. On the leading strand, DNA is synthesized continuously, whereas on the lagging strand, DNA is synthesized in short stretches. The DNA fragments are joined by DNA ligase (not shown). You isolate a cell strain in which the joining together of Okazaki fragments is impaired and suspect that a mutation has occurred in an enzyme found at the replication fork. Which enzyme is most likely to be mutated?

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Figure 9.10 You isolate a cell strain in which the joining together of Okazaki fragments is impaired and suspect that a mutation has occurred in an enzyme found at the replication fork. Which enzyme is most likely to be mutated?

Origin of Replication
RNA primer
5'
5'
femplate
strands
Leading
strand
DNA
Lagging
strand
polymerase
3 5'
5'
3'
5
Helicase
DNA
Okazaki
fragment
DNA
RNA
ligase
palymerase
primer
Figure 9.10 A replication fork is formed by the opening of the origin of replication, and helicase separates the
DNA strands. An RNA primer is synthesized, and is elongated by the DNA polymerase. On the leading strand,
DNA is synthesized continuously, whereas on the lagging strand, DNA is synthesized in short stretches. The DNA
fragments are joined by DNA ligase (not shown).
You isolate a cell strain in which the joining together of Okazaki fragments is impaired and suspect that
a mutation has occurred in an enzyme found at the replication fork. Which enzyme is most likely to be
mutated?
Transcribed Image Text:Origin of Replication RNA primer 5' 5' femplate strands Leading strand DNA Lagging strand polymerase 3 5' 5' 3' 5 Helicase DNA Okazaki fragment DNA RNA ligase palymerase primer Figure 9.10 A replication fork is formed by the opening of the origin of replication, and helicase separates the DNA strands. An RNA primer is synthesized, and is elongated by the DNA polymerase. On the leading strand, DNA is synthesized continuously, whereas on the lagging strand, DNA is synthesized in short stretches. The DNA fragments are joined by DNA ligase (not shown). You isolate a cell strain in which the joining together of Okazaki fragments is impaired and suspect that a mutation has occurred in an enzyme found at the replication fork. Which enzyme is most likely to be mutated?
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