The image below shows the base cytosine and a methylated form of cytosine that occurs frequently in the human genome. Use your knowledge of DNA structure to answer the following question: a) Does methylation of cytosine affect its ability to base-pair with guanine? Explain b) Could methylation of cytosine affect the binding of a protein that interacts with a C-G base-pair in the major groove? Explain your answer.

Human Anatomy & Physiology (11th Edition)
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Author:Elaine N. Marieb, Katja N. Hoehn
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The image below shows the base cytosine and a methylated form of cytosine that occurs frequently in the human genome. Use your knowledge of DNA structure to answer the following question:

a) Does methylation of cytosine affect its ability to base-pair with guanine? Explain

b) Could methylation of cytosine affect the binding of a protein that interacts with a C-G base-pair in the major groove? Explain your answer.

 

 

NH₂
DNA
Cytosine
Methylation
=
Demethylation
NH₂
CH3
DŇA
5-Methylcytosine
Transcribed Image Text:NH₂ DNA Cytosine Methylation = Demethylation NH₂ CH3 DŇA 5-Methylcytosine
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