Answered: NuH H E HO Nu + H₂O Ο NH3* 8 NH3 2-03PO…

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Biology

NuH H E HO Nu + H₂O Ο NH3* 8 NH3 2-03PO 8 N L-Ser 9 H

Essentials of Pharmacology for Health Professions

7th Edition

ISBN:9781305441620

Author:WOODROW

Publisher:WOODROW

Chapter5: Abbreviations And Systems Of Measurement

Section: Chapter Questions

Problem 11CRQ

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Question

Coenzyme 8, in conjunction with the appropriate enzyme E can carry out the following
transformation of L-Ser to 9, called β-replacement. Provide a reasonable mechanism that starts
with the adduct of L-Ser and 8. You may invoke any general acids/general bases that you need
for the catalysis. When you have the adduct of 9 and 8, simply write “transamination” above an
arrow that leads to 9.

NuH
H
E
HO
Nu
+ H₂O
Ο
NH3*
8
NH3
2-03PO
8
N
L-Ser
9
H

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