The following two questions relate to the same scenario. James is using a malaria parasite membrane preparation to try to study the Na* pump 'PfATP4' Cipargamin is a known inhibitor of PfATP4. James is interested in whether Compound A or Compound B might be PfATP4 inhibitors too. He obtains the data below. Pi produced (% of Pi produced in 152 mM Na* Control) 20 20 40 09 60 40 120 100 80 Compound A Compound B + + + + ' 1 + + + + 152 mM Na+ 152 mM Na++ cipargamin 0 mM Na* 0 mM Na⭑+ cipargamin
The following two questions relate to the same scenario. James is using a malaria parasite membrane preparation to try to study the Na* pump 'PfATP4' Cipargamin is a known inhibitor of PfATP4. James is interested in whether Compound A or Compound B might be PfATP4 inhibitors too. He obtains the data below. Pi produced (% of Pi produced in 152 mM Na* Control) 20 20 40 09 60 40 120 100 80 Compound A Compound B + + + + ' 1 + + + + 152 mM Na+ 152 mM Na++ cipargamin 0 mM Na* 0 mM Na⭑+ cipargamin
Chapter14: Formula Method
Section: Chapter Questions
Problem 40SST
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Can someone please help answer the two questions below based on the given scenario thanks!
What can James accurately conclude from the data shown?
Select one or more:
a.Na+-dependent ATPase activity is inhibited by cipargamin.
b.All the ATPases in the parasite membrane preparation are Na+-dependent.
c.PfATP4 transports K+ as well as Na+.
d.The V-type H+ ATPase accounts for a larger fraction of total membrane ATPase activity than PfATP4.
e.There is at least one Na+-sensitive ATPase in the parasite membrane preparation.
f.Compound B inhibits an ATPase, but not a Na+-dependent ATPase.
The data are consistent with Compound B, but not Compound A, being a PfATP4 inhibitor.
a. True
b. False
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