Answered: The following two questions relate to…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Can someone please help answer the two questions below based on the given scenario thanks!

What can James accurately conclude from the data shown?

Select one or more:

a.Na⁺-dependent ATPase activity is inhibited by cipargamin.

b.All the ATPases in the parasite membrane preparation are Na⁺-dependent.

c.PfATP4 transports K⁺ as well as Na⁺.

d.The V-type H⁺ ATPase accounts for a larger fraction of total membrane ATPase activity than PfATP4.

e.There is at least one Na⁺-sensitive ATPase in the parasite membrane preparation.

f.Compound B inhibits an ATPase, but not a Na⁺-dependent ATPase.

The data are consistent with Compound B, but not Compound A, being a PfATP4 inhibitor.

a. True

b. False

The following two questions relate to the same scenario.
James is using a malaria parasite membrane preparation to
try to study the Na* pump 'PfATP4' Cipargamin is a known
inhibitor of PfATP4. James is interested in whether
Compound A or Compound B might be PfATP4 inhibitors
too. He obtains the data below.
Pi produced (% of Pi produced
in 152 mM Na* Control)
20
20
40
09
60
40
120
100
80
Compound A
Compound B
+ + + +
'
1
+ + + +
152 mM Na+
152 mM Na++
cipargamin
0 mM Na*
0 mM Na⭑+
cipargamin

Definition Definition Organism that lives in the body of another organism and obtains food at the expense of the host. A parasite can directly or indirect harm the host. There are two kinds of parasites: internal and external. An internal parasite lives inside another organism and is known as an endoparasite. An external parasite lives on the body surface of the host and is known as an ectoparasite. Protozoa and helminths are examples of major human parasites.

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