The following two questions relate to the same scenario. James is using a malaria parasite membrane preparation to try to study the Na* pump 'PfATP4' Cipargamin is a known inhibitor of PfATP4. James is interested in whether Compound A or Compound B might be PfATP4 inhibitors too. He obtains the data below. Pi produced (% of Pi produced in 152 mM Na* Control) 20 20 40 09 60 40 120 100 80 Compound A Compound B + + + + ' 1 + + + + 152 mM Na+ 152 mM Na++ cipargamin 0 mM Na* 0 mM Na⭑+ cipargamin

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter14: Formula Method
Section: Chapter Questions
Problem 40SST
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Can someone please help answer the two questions below based on the given scenario thanks! 

What can James accurately conclude from the data shown?

Select one or more:

a.Na+-dependent ATPase activity is inhibited by cipargamin.
b.All the ATPases in the parasite membrane preparation are Na+-dependent.
c.PfATP4 transports K+ as well as Na+.

d.The V-type H+ ATPase accounts for a larger fraction of total membrane ATPase activity than PfATP4.

e.There is at least one Na+-sensitive ATPase in the parasite membrane preparation.

f.Compound B inhibits an ATPase, but not a Na+-dependent ATPase.

 

The data are consistent with Compound B, but not Compound A, being a PfATP4 inhibitor.

a. True
b. False
The following two questions relate to the same scenario.
James is using a malaria parasite membrane preparation to
try to study the Na* pump 'PfATP4' Cipargamin is a known
inhibitor of PfATP4. James is interested in whether
Compound A or Compound B might be PfATP4 inhibitors
too. He obtains the data below.
Pi produced (% of Pi produced
in 152 mM Na* Control)
20
20
40
09
60
40
120
100
80
Compound A
Compound B
+ + + +
'
1
+ + + +
152 mM Na+
152 mM Na++
cipargamin
0 mM Na*
0 mM Na⭑+
cipargamin
Transcribed Image Text:The following two questions relate to the same scenario. James is using a malaria parasite membrane preparation to try to study the Na* pump 'PfATP4' Cipargamin is a known inhibitor of PfATP4. James is interested in whether Compound A or Compound B might be PfATP4 inhibitors too. He obtains the data below. Pi produced (% of Pi produced in 152 mM Na* Control) 20 20 40 09 60 40 120 100 80 Compound A Compound B + + + + ' 1 + + + + 152 mM Na+ 152 mM Na++ cipargamin 0 mM Na* 0 mM Na⭑+ cipargamin
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