What environmental conditions might play a role in a person's tendency to contract a disease? Genetics can also play a role in a person's tendency to contract a certain disease, but many human diseases do not have a straightforward single-gene cause. What are some diseases you can think of that may be inherited--caused by certain genes?
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What environmental conditions might play a role in a person's tendency to contract a disease? Genetics can also play a role in a person's tendency to contract a certain disease, but many human diseases do not have a straightforward single-gene cause. What are some diseases you can think of that may be inherited--caused by certain genes?
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- A human gene called the β-globin gene encodes a polypeptide that functions as a subunit of the protein known as hemoglobin. Hemoglobin carries oxygen within red blood cells. In human populations, the β-globin gene can be found as the more common allele called the HbA allele, but it can also be found as theHbS allele. Individuals who have two copies of the HbS allele have the disease called sickle cell disease. Are the followingexamples a description of genetics at the molecular, cellular, organism, or population level?A. The HbS allele encodes a polypeptide that functions slightly differently from the polypeptide encoded by the HbA allele.B. If an individual has two copies of the HbS allele, that person’s red blood cells take on a sickle shape. C. Individuals who have two copies of the HbA allele do not have sickle cell disease, but they are not resistant to malaria. People who have one HbA allele and one HbS allele do not have sickle cell disease, and they are resistant to malaria.…Most of the genetic information we will get from our genome will not be hard evidence that we will or we won’t get a disease but is rather only probabilistic evidence. a. What does this mean? b. Why might knowing a single gene not tell you if you will get a particular condition?One unexpected result of the sequencing of the human genome was the finding that mutations in a single gene can be responsible for multiple distinct disorders. How do you think mutations in a single gene can have such diverse effects?
- In an epic battle, the Green Goblin was able to wound Spider-Man and collect a sample of his cells. Utilizing a HuMouse model organism, the Goblin got the mutated chromosomes into the animals and began breeding them to determine the basis of their chromosomal inheritance. In the process of conducting his research, he discovered the gene associated with spider-like powers are actually three distinct genes: one for spider sense; one for super strength; one for enhanced agility. All genes appear to be dominant, so the Goblin runs a test cross and gets the following results: Phenotype Agility Number of Progeny 94 Agility and Sense 3 All 3 Powers 580 Sense 40 Strength and Agility Strength and Sense Strength 45 89 5 No Powers 592 What is the map distance between Strength and Agility genes? (Enter your number as map units, or centiMorgans, but without units)people with osteogenesis imperfecta have a dominant mutation in one of the two genes that produce type 1 collagen. people with OI have weak bones, bkuish color in teh whites of eyes, and a variety of afflictions that cause weakness in their joint and teeth. However, some people can carry the mutation but have no symptoms. Thus, families can unknowingly transmit the mutation but does not express the OI phenotype. This is an example of which of the following? a. incomplete penetrance b. variable expressivity c. epistasis d. incomplete dominanceGenetics is commonly seen as being grouped into several general areas: transmission, molecular, and population/evolution. Which biological processes are studied in transmission genetics?
- In this unit you learned about the Hershey and Chase experiment that showed that DNA is the genetic material of bacteriophage viruses, which was fairly simple given that viruses only have DNA and protein components. Describe an experiment you could perform or evidence you could observe that would prove that DNA is the genetic material that results in inheritance of traits (through gene expression) in a multicellular animal. (NOTE: do not describe the Hershey and Chase experiment or the Griffith experiment in your answer)Select the statements that describe the effect of copy number variation on human phenotypes. An increase in copy number can cause gene function loss due to chromosome breaks. A decrease in copy number can cause Mendelian autosomal disorders due to point mutations. Oncogene overexpression due to a gain in copy number can cause cancer. Increase in the copy number of immunity genes can result in increased pathogen resistance. Copy number variations are associated with polygenic disorders such as schizophrenia.Gene mutations can be classified in two major ways:(1) hereditary or germline mutations that are inherited from a parent and are present throughout a person’s life in virtually every cell in the body.(2) acquired or somatic mutations that occur at some time during a person’s life and are present only in certain cells, not in every cell in the body.If there is no family history of a particular disease but a child has the disease then it may have arisen due to a(n) ________ mutation early during development. A) acquired B) inherited C) silent D) transition
- Fragile X syndrome, caused by a change in the FMR1 gene, is the most common form of intellectual disability. In patients with this syndrome, a small part of the gene is repeated several times in one area of the chromosome. This defect in the gene makes the body unable to produce adequate amounts of a protein needed for normal brain functioning. In males, this syndrome causes a moderate intellectual disability, and in females, a mild intellectual disability. A family that exhibits Fragile X syndrome is shown in the pedigree. In the pedigree, squares represent males and circles represent females. Shaded symbols represent a person with the disorder. Which of the following correctly predicts the outcome if offspring 11 mated with a homozygous normal female, based on the inheritance pattern shown in the pedigree? A - The male offspring would exhibit Fragile X syndrome because Fragile X is an X-linked recessive trait. B - The female offspring would exhibit Fragile X syndrome because Fragile…Fragile X syndrome, caused by a change in the FMR1 gene, is the most common form of intellectual disability. In patients with this syndrome, a small part of the gene is repeated several times in one area of the chromosome. This defect in the gene makes the body unable to produce adequate amounts of a protein needed for normal brain functioning. In males, this syndrome causes a moderate intellectual disability, and in females, a mild intellectual disability. A family that exhibits Fragile X syndrome is shown in the pedigree. In the pedigree, squares represent males and circles represent females. Shaded symbols represent a person with the disorder. Which of the following correctly predicts the outcome if offspring 11 mated with a homozygous normal female, based on the inheritance pattern shown in the pedigree? The male offspring would exhibit Fragile X syndrome because Fragile X is an X-linked recessive trait. The female offspring would exhibit Fragile X syndrome because Fragile X…1. What is an allele? 2. What is a point mutation? 3. How are point mutations related to alleles? Use these sites to find the answer please: https://www.britannica.com/story/whats-the-difference-between-a-gene-and-an-allele http://rosalind.info/glossary/point-mutation/