Normal (nonmutant) tumor-suppressor genes often functiona. as negative regulators of cell division.b. in the maintenance of genome integrity.c. in the stimulation of cell division.d. as both a and b.

Human Anatomy & Physiology (11th Edition)
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Normal (nonmutant) tumor-suppressor genes often function
a. as negative regulators of cell division.
b. in the maintenance of genome integrity.
c. in the stimulation of cell division.
d. as both a and b.

Expert Solution
Introduction

Cancer is defined as the biological disorder in which the cells undergo uncontrolled growth and cell division. Cancer occurs when the cells proliferate in an uncontrolled manner; the excess tissue that develops is called as a neoplasm or tumor.

 

Explanation

Answer: Option d. “as both a and b”.

Tumor suppressor gene controls the abnormal growth of the cell. They play an important role in the inhibition of cancer in the body. The primary function of the tumor-suppressor gene is negative regulation of cell division. They inhibit the abnormal proliferation, which effectively inhibits the production of cancer in the body. Secondly, they help in maintaining the genome integrity in the cells, as they do not allow alteration in gene sequences, due to which the cells maintain the integrity of the genome. Therefore, the option d is correct.

 

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