Need help, please. In this scenario, a patient has beriberi. Beriberi patients can be treated through a thiamine-enriched diet. The patient was put on a thiamine-enriched diet but not all of their symptoms were alleviated. Through genetic testing, it was found that there was also a small defect in pyruvate dehydrogenase phosphatase that decreases its normal activity. 1. Explain why this genetic defect can cause beriberi symptoms (i.e. high pyruvate levels after a high-carb meal). 2. Why did thiamine supplementation not alleviate the symptoms for this patient?
Need help, please. In this scenario, a patient has beriberi. Beriberi patients can be treated through a thiamine-enriched diet. The patient was put on a thiamine-enriched diet but not all of their symptoms were alleviated. Through genetic testing, it was found that there was also a small defect in pyruvate dehydrogenase phosphatase that decreases its normal activity. 1. Explain why this genetic defect can cause beriberi symptoms (i.e. high pyruvate levels after a high-carb meal). 2. Why did thiamine supplementation not alleviate the symptoms for this patient?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Need help, please.
In this scenario, a patient has beriberi. Beriberi patients can be treated through a thiamine-enriched diet. The patient was put on a thiamine-enriched diet but not all of their symptoms were alleviated. Through genetic testing, it was found that there was also a small defect in pyruvate dehydrogenase phosphatase that decreases its normal activity.
1. Explain why this genetic defect can cause beriberi symptoms (i.e. high pyruvate levels after a high-carb meal).
2. Why did thiamine supplementation not alleviate the symptoms for this patient?
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