Citric acid (or citrate) is an allosteric inhibitor of one of the first enzymes in glycolysis. How, in general, will it af Glucose Inhibits why Glycolysis Fructose-6-phosphate Phosphofructokinase Fructose-1,6-bisphosphate Pyruvate AMP Stimulates Inhibits
Citric acid (or citrate) is an allosteric inhibitor of one of the first enzymes in glycolysis. How, in general, will it af Glucose Inhibits why Glycolysis Fructose-6-phosphate Phosphofructokinase Fructose-1,6-bisphosphate Pyruvate AMP Stimulates Inhibits
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Transcribed Image Text:Citric acid (or citrate) is an allosteric inhibitor of one of the first enzymes in glycolysis. How, in general, will it affect cellular respiration?
**Diagram Explanation:**
The diagram illustrates the interplay between glycolysis and the citric acid cycle, along with the regulation of phosphofructokinase, an enzyme in glycolysis. Key components are:
1. **Glycolysis Pathway (light blue box):**
- **Substrate:** Glucose is converted into fructose-6-phosphate.
- **Phosphofructokinase:** This enzyme converts fructose-6-phosphate to fructose-1,6-bisphosphate.
- **End Product:** Pyruvate.
2. **Citric Acid Cycle (red box):**
- **Acetyl CoA:** Formed from pyruvate entering the cycle.
- **Citric Acid:** The cycle produces citrate, which feeds back to inhibit phosphofructokinase.
3. **Regulation:**
- **Inhibition:** Citrate inhibits phosphofructokinase, slowing glycolysis.
- **Stimulation:** AMP stimulates phosphofructokinase, enhancing glycolysis.
- ATP is shown providing energy, with excess ATP inhibiting the process.
**Question and Options:**
How will citric acid abundance affect cellular respiration?
- O Glycolysis will slow down when citric acid is abundant.
- O It will compete with glucose for the active site of the enzyme.
- O It will stop the citric acid cycle when pyruvate is abundant.
- O All of the above.
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