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Epinephrine signaling activates PKA, which leads to phosphorylation of pyruvate kinase in liver cells. The muscle cell pyruvate kinase isozyme CANNOT be phosphorylated by PKA. Why is this important? O Muscle cells do not carry out gluconeogenesis, while liver cells do. O When epinephrine is released, muscle cells must be able to generate ATP; liver cells must produce glucose. O Glucagon signaling regulates muscle cell glucose metabolism, while liver cell glucose metabolism is mainly controlled by epinephrine. O Regulation of glycolysis is less important in muscle cells than in liver cells.

Epinephrine signaling activates PKA, which leads to phosphorylation of pyruvate kinase in liver cells. The muscle cell pyruvate kinase isozyme CANNOT be phosphorylated by PKA. Why is this important? O Muscle cells do not carry out gluconeogenesis, while liver cells do. O When epinephrine is released, muscle cells must be able to generate ATP; liver cells must produce glucose. O Glucagon signaling regulates muscle cell glucose metabolism, while liver cell glucose metabolism is mainly controlled by epinephrine. O Regulation of glycolysis is less important in muscle cells than in liver cells.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Epinephrine signaling activates PKA, which leads to phosphorylation of pyruvate kinase in liver cells. The muscle cell pyruvate kinase isozyme CANNOT be phosphorylated by PKA. Why is this important? Muscle cells do not carry out gluconeogenesis, while liver cells do. When epinephrine is released, muscle cells must be able to generate ATP; liver cells must produce glucose. O Glucagon signaling regulates muscle cell glucose metabolism, while liver cell glucose metabolism is mainly controlled by epinephrine. Regulation of glycolysis is less important in muscle cells than in liver cells.
Transcribed Image Text:Epinephrine signaling activates PKA, which leads to phosphorylation of pyruvate kinase in liver cells. The muscle cell pyruvate kinase isozyme CANNOT be phosphorylated by PKA. Why is this important? Muscle cells do not carry out gluconeogenesis, while liver cells do. When epinephrine is released, muscle cells must be able to generate ATP; liver cells must produce glucose. O Glucagon signaling regulates muscle cell glucose metabolism, while liver cell glucose metabolism is mainly controlled by epinephrine. Regulation of glycolysis is less important in muscle cells than in liver cells.
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