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NAD+ NADH + H+ CH3-CH₂-OH ADH Ethanol NAD+ NADH + H+ H CH3-C=O-ALDH Acetaldehyde O CH3-C-OH Acetate

NAD+ NADH + H+ CH3-CH₂-OH ADH Ethanol NAD+ NADH + H+ H CH3-C=O-ALDH Acetaldehyde O CH3-C-OH Acetate

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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This is the question: Ethanol metabolism has been part of the human diet for centuries. Ethanol cannot be excreted and must be metabolized by the liver using the enzyme alcohol dehydrogenase in a two step reaction:

Excess consumption of ethanol leads to the accumulation of NADH. What effect would a high concentration of NADH have on metabolic pathways and consequently the body. Choose as least two pathways to describe the effect.

NAD+ NADH + H+ CH3-CH₂-OH ADH Ethanol NAD+ NADH + H+ H CH3-C=O-ALDH Acetaldehyde O CH3-C-OH Acetate
Transcribed Image Text:NAD+ NADH + H+ CH3-CH₂-OH ADH Ethanol NAD+ NADH + H+ H CH3-C=O-ALDH Acetaldehyde O CH3-C-OH Acetate
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