Mismatches introduced during DNA replication are detected and repaired efficiently by the “Mut” system of E. coli. (A) Please outline the steps in mismatch detection and repair by this system. (B) What is the historical reason for naming these genes “Mut” in the first place? (C) How might you identify bacterial strains with defects in the “Mut” system? (D) It has been observed that recombination-deficient mutations are usually lethal when they are combined with mutations in the mismatch repair pathway you just described. Why is that?
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
Mismatches introduced during
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