Melanoma, 45Colon cancer, 40Sarcoma, 45BreastLung cancer, 53cancer, 32Stomachcancer, 50Brain cancer, 18Osteosarcoma, 3Leukemia, 19Rhabdomyosarcoma, 14Answer the following subparts :-A. What do you notice in this pedigree as compared to Rb or BRCA1/2?B. Why do you think that so many cancer types are associated with inherited defects inp53?Please need detailed answer I want to learn please please I will upvote god promise|

A pedigree is a hereditary representation of family tree by displaying in the form of diagrams which…

Answered: Melanoma, 45| Colon cancer, 40 Sarcoma,…

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter12: Genes And Cancer

Section: Chapter Questions

Problem 12QP

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Similar questions

How can the retinoblastoma trait be inherited in a dominant fashion if the deletion of the RB gene is recessive to the wild-type RB+ allele?
18
What characteristics of the pedigree shown in Figure 23.1 suggest thatpancreatic cancer in this family is inherited as an autosomal dominanttrait?
17
Pancreatic cancer is clearly inherited as an autosomal dominant trait in the family illustrated in Figure 23.1. Yet most cases of pancreatic cancer are sporadic, appearing as isolated cases in families with no obvious inheritance. How can a trait be strongly inherited in one family and not inherited in another?
9 a,b,c
Explain why familial breast cancer shows a dominant pattern of inheritance in a pedigree even though it is recessive at the cellular level.
Retinoblastoma: The Hits Just Keep Coming Part I – White Spots Questions Whitt noted leukocoria and strabismus. Define these terms. Based on what you know so far, create a pedigree that depicts the prevalence of cancer in this family. Indicate Kay as the proband. Consider the pedigree that you just drew. What mode of inheritance seems most likely? Justify your prediction. What is the difference between a sporadic cancer and an inherited (or familial) cancer? Which is most common? Based on the pedigree you drew; do you think that the cancer in this family tree is sporadic or inherited? Why? Briefly, describe the fundamental problem that distinguishes a cancer cell from a non-cancerous cell.
Retinoblastoma can be seen as a familial cancer, inherited in an autosomal recessive manner (RB-/RB-), individuals heterozygous for the RB+ and RB- alleles can develop tumor as a result of… A mitotic crossover that leads to homozygosity for RB+ in some cells and RB- in other cells A meiotic mutation in the RB+ allele that leads to homozygosity for RB+ A somatic mutation in the RB- allele that leads to homozygosity for RB+ The fact that RB- is dominant to RB+
The propensity to develop retinal cancer can run in pedigrees of certain families. You have learned about the role of the retinoblastoma (Rb) protein in the cell cycle. A heterozygous individual (genotype = Rbm / Rb+) that inherits a mutant allele of the Rb gene (Rbm) as well as a normal allele of the Rb gene (Rb+) is at significant risk for developing cancer of the retina. The best explanation for this is that… A. the Rb(m) allele is dominant to the Rb(+) allele. B. a mutation in the Rb(+) allele can result in a Rb(m) / Rb(m) genotype in certain cells. C. the retina is frequently exposed to UV rays D. the Rb(m) allele directly converts the Rb(+) allele to another Rb(m) allele. E. the cells of the retina carry more than two copies of the Rb gene
A female patient 19 years old, whose symptoms areanemia and internal bleeding due to a massive buildupof leukemic white blood cells, is diagnosed withchronic myelogenous leukemia (CML). Karyotypeanalysis shows that the leukemic cells of this patientare heterozygous for a reciprocal translocation involving chromosomes 9 and 22. However, none of thenormal, nonleukemic cells of this patient contain thetranslocation. Which of the following statements istrue and which is false?a. The translocation results in the inactivation (loss offunction) of a tumor-suppressor gene.b. The translocation results in the inactivation (loss offunction) of an oncogene.c. There is a 50% chance that any child of this patientwill have CML.d. This patient is a somatic mosaic in terms of thekaryotype.e. DNA extracted from leukemic cells of this patient,if taken up by normal mouse tissue culture cells,could potentially transform the mouse cells intocells capable of causing tumors.f. The normal function of the…
Hello, i understand the question, but i only need to know which option is right, no need for explanation. I mean jsut say which option, thanks in advance.

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