Q3. Cystic fibrosis is an autosomal recessive inherited disorder that causes severe damage to the lungs, digestive system and other organs in the body. Cystic fibrosis affects the cells that produce mucus, sweat and digestive juices. The disease occurs when there is a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which is the gene responsible for the movements of negatively charged particles known as chloride ions into and out of cells. Using the base pairing rules and the codon table, determine the mRNA and protein sequences produced by the CFTR gene's segment (below). Transeription begins at and includes the bold and underlined G nucleotide. CFTR gene's segment. - GCGATGTACAACCGAGGGTAAAAAA - 3' coding sequence a) The DNA template sequence 3'.. ...5' b) Fill in the first 9 nucleotides of the primary/ nascent mRNA transcribed from Gene A. 5'-.... -3' c) Protein N-term... . . C- terminus d) Exposure to cigarette smoke (a known mutagen) deletes base #9 (highlighted in red cytosine) on the gene's segment above. Now determine the resulting protein sequences of the new mutant gene's segment. e) Explain the effect of this mutation on the function of the protein. What is the type of this mutation? Relate to symptoms of CF disease (see the above symptoms). THE GENETIC CODE Second letter A UCU UAU ) Tyr UAC UGU Cys UU Phe UUC UCC UGC Ser UAA Stop UGA Stop A UAG Stop UGG Trp G UUA UCA Leu UUG UCG CUU CCU CAU CGU CAC CAA His CUC CC CGC Leu Pro CCA CCG Arg CUA CGA CUG Gin CAG CGG ACU ACC AUU AAU AGU Ser AUC lle AAC Asn AGC Thr A AUA ACA AAA Lys AGG AGA AUG Met ACG AAG Arg GGU Asp GUU GCU GAU GUC Val GCC GAC GGC Ala Gly GAA Glu GUA GCA GGA GUG GCG GAG GGG Third letter DCAG POAG コ0てO First letter
Q3. Cystic fibrosis is an autosomal recessive inherited disorder that causes severe damage to the lungs, digestive system and other organs in the body. Cystic fibrosis affects the cells that produce mucus, sweat and digestive juices. The disease occurs when there is a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which is the gene responsible for the movements of negatively charged particles known as chloride ions into and out of cells. Using the base pairing rules and the codon table, determine the mRNA and protein sequences produced by the CFTR gene's segment (below). Transeription begins at and includes the bold and underlined G nucleotide. CFTR gene's segment. - GCGATGTACAACCGAGGGTAAAAAA - 3' coding sequence a) The DNA template sequence 3'.. ...5' b) Fill in the first 9 nucleotides of the primary/ nascent mRNA transcribed from Gene A. 5'-.... -3' c) Protein N-term... . . C- terminus d) Exposure to cigarette smoke (a known mutagen) deletes base #9 (highlighted in red cytosine) on the gene's segment above. Now determine the resulting protein sequences of the new mutant gene's segment. e) Explain the effect of this mutation on the function of the protein. What is the type of this mutation? Relate to symptoms of CF disease (see the above symptoms). THE GENETIC CODE Second letter A UCU UAU ) Tyr UAC UGU Cys UU Phe UUC UCC UGC Ser UAA Stop UGA Stop A UAG Stop UGG Trp G UUA UCA Leu UUG UCG CUU CCU CAU CGU CAC CAA His CUC CC CGC Leu Pro CCA CCG Arg CUA CGA CUG Gin CAG CGG ACU ACC AUU AAU AGU Ser AUC lle AAC Asn AGC Thr A AUA ACA AAA Lys AGG AGA AUG Met ACG AAG Arg GGU Asp GUU GCU GAU GUC Val GCC GAC GGC Ala Gly GAA Glu GUA GCA GGA GUG GCG GAG GGG Third letter DCAG POAG コ0てO First letter
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
please only answer part d and e
Transcribed Image Text:Q3.
Cystic fibrosis is an autosomal recessive inherited disorder that causes
severe damage to the lungs, digestive system and other organs in the body. Cystic fibrosis
affects the cells that produce mucus, sweat and digestive juices. The disease occurs when
there is a mutation in the cystic fibrosis transmembrane conductance regulator
(CFTR) gene, which is the gene responsible for the movements of negatively charged
particles known as chloride ions into and out of cells.
Using the base pairing rules and the codon table, determine the mRNA and protein
sequences produced by the CFTR gene's segment (below). Transeription begins at
and includes the bold and underlined G nucleotide.
CFTR gene's segment. - GCGATGTACAACCGAGGGTAAAAAA - 3' coding
sequence
a) The DNA template sequence 3'..
...5'
b) Fill in the first 9 nucleotides of the primary/ nascent mRNA transcribed
from Gene A.
5'-....
-3'
c) Protein N-term...
. . C- terminus
d) Exposure to cigarette smoke (a known mutagen) deletes base #9 (highlighted
in red cytosine) on the gene's segment above.
Now determine the resulting protein sequences of the new mutant
gene's segment.
e) Explain the effect of this mutation on the function of the protein. What is
the type of this mutation? Relate to symptoms of CF disease (see the above
symptoms).
Transcribed Image Text:THE GENETIC CODE
Second letter
A
UCU
UAU )
Tyr
UAC
UGU Cys
UU
Phe
UUC
UCC
UGC
Ser
UAA Stop UGA Stop A
UAG Stop UGG Trp G
UUA
UCA
Leu
UUG
UCG
CUU
CCU
CAU
CGU
CAC
CAA
His
CUC
CC
CGC
Leu
Pro
CCA
CCG
Arg
CUA
CGA
CUG
Gin
CAG
CGG
ACU
ACC
AUU
AAU
AGU
Ser
AUC lle
AAC Asn
AGC
Thr
A
AUA
ACA
AAA
Lys AGG
AGA
AUG Met ACG
AAG
Arg
GGU
Asp
GUU
GCU
GAU
GUC
Val
GCC
GAC
GGC
Ala
Gly
GAA
Glu
GUA
GCA
GGA
GUG
GCG
GAG
GGG
Third letter
DCAG POAG
コ0てO
First letter
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