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Match the following phenotype with its most likely to be mutation causes. 1._____  Mutant human cells die, and you observe that the DNA in the cells is not condensed prior to cell division 2._____  E. coli DNA replication does not take place, and you observe no single-stranded DNA in the mutant cells 3._____ In mutant E. coli, you observe Pol III core proteins floating freely in the cell, removed from the holoenzyme complex 4._____ In mutant E. coli, you see very low processivity and you observe high disassociation of Pol III and the DNA strand

Match the following phenotype with its most likely to be mutation causes. 1._____  Mutant human cells die, and you observe that the DNA in the cells is not condensed prior to cell division 2._____  E. coli DNA replication does not take place, and you observe no single-stranded DNA in the mutant cells 3._____ In mutant E. coli, you observe Pol III core proteins floating freely in the cell, removed from the holoenzyme complex 4._____ In mutant E. coli, you see very low processivity and you observe high disassociation of Pol III and the DNA strand

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Match the following phenotype with its most likely to be mutation causes.

1._____  Mutant human cells die, and you observe that the DNA in the cells is not condensed prior to cell division

2._____  E. coli DNA replication does not take place, and you observe no single-stranded DNA in the mutant cells

3._____ In mutant E. coli, you observe Pol III core proteins floating freely in the cell, removed from the holoenzyme complex

4._____ In mutant E. coli, you see very low processivity and you observe high disassociation of Pol III and the DNA strand

Protein Domain А) Pol II B) Pol III С) Pol II D) SBP E) SBP F) Tao protein G) Tao protein H) Pol & I) Cdt6 J) Cdt6 K) DNA gyrase Mutations Asp to Ala Asp to Ala Asp to Ala Arg to Lys Arg to Pro Thr to Ala Gly to Pro Arg to Ala Glu to Asp Lys to Asp Arg to Glu Phe to Ala Ala to His Arg to Ala Arg to Lys Thr to Ala Arg to Asp Met to Ala Thumb domain Palm domain Fingers domain DNA binding domain DNA binding domain w ww Thumb domain Thumb domain Thumb domain ORC-interacting domain ORC-interacting domain DNA-binding domain exonuclease domain DNA binding domain DNA binding domain DNA binding domain L) Rnase H M) DNA ligase N) Histone H1 0) Histone H1 P) Pol a Q) Pol a R) DNA Helicase S) Sliding Clamp T) Telomerase Thumb domain Palm domain ATPase domain Pol III-binding domain DNA binding domain Ala to Gln Arg to Glu
Transcribed Image Text:Protein Domain А) Pol II B) Pol III С) Pol II D) SBP E) SBP F) Tao protein G) Tao protein H) Pol & I) Cdt6 J) Cdt6 K) DNA gyrase Mutations Asp to Ala Asp to Ala Asp to Ala Arg to Lys Arg to Pro Thr to Ala Gly to Pro Arg to Ala Glu to Asp Lys to Asp Arg to Glu Phe to Ala Ala to His Arg to Ala Arg to Lys Thr to Ala Arg to Asp Met to Ala Thumb domain Palm domain Fingers domain DNA binding domain DNA binding domain w ww Thumb domain Thumb domain Thumb domain ORC-interacting domain ORC-interacting domain DNA-binding domain exonuclease domain DNA binding domain DNA binding domain DNA binding domain L) Rnase H M) DNA ligase N) Histone H1 0) Histone H1 P) Pol a Q) Pol a R) DNA Helicase S) Sliding Clamp T) Telomerase Thumb domain Palm domain ATPase domain Pol III-binding domain DNA binding domain Ala to Gln Arg to Glu
Expert Solution
Question 1

The mutation for question 1 is in the histone H1 proteins. 

Histones along with condensins are responsible for chromatin condensation. 

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