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kanin Product Substrate(non-cognate/wrong) km En ki Errk. (1-Err) kg. (1-Em) k (1-4) kg ik Ku Mi Erk. II (1-Em) k Substrate(cognate/right) Reactant

kanin Product Substrate(non-cognate/wrong) km En ki Errk. (1-Err) kg. (1-Em) k (1-4) kg ik Ku Mi Erk. II (1-Em) k Substrate(cognate/right) Reactant

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May I ask for a detailed explanation of this figure ( retrieved from Chunhong Long and Jin Yu, “Balancing Non-Equilibrium Driving with Nucleotide Selectivity at Kinetic Checkpoints in Polymerase Fidelity Control”, Entropy 20, 306 (2018), https://pubmed.ncbi.nlm.nih.gov/33265397/ ) ?

Description of figure: The kinetic scheme for the three-state nucleotide addition cycle (NAC) with selection. Since the cognate (right) and non-cognate (wrong) nucleotide species are differentiated in the substrate state III, one splits the cycle into two pathways for the right and wrong substrate species. Correspondingly, one has a population vector Π=(PI,PII,PIII^r,PIII^w)^T to describe the overall state probability distributions.

kanin Product Substrate(non-cognate/wrong) k En ki Errk. (1-Err) kg. (1-Em) k (1-4) kg ik Ku Mi Erk. II (1-Em) k III Substrate(cognate/right) Reactant
Transcribed Image Text:kanin Product Substrate(non-cognate/wrong) k En ki Errk. (1-Err) kg. (1-Em) k (1-4) kg ik Ku Mi Erk. II (1-Em) k III Substrate(cognate/right) Reactant
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