It is hypothesized that there are fluctuations in norepinephrine (NE) levels which accompany fluctuations in affect with bipolar affective disorder (manic-depressive illness). Thus, during depressive states, NE levels drop; during manic states, NE levels increase. To test this relationship, researchers measured the level of NE by measuring the metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG in micro gram per 24 hour) in the patient's urine experiencing varying levels of mania/depression. Increased levels of MHPG are correlated with increased metabolism (thus higher levels) of central nervous system NE. Levels of mania/depression were also recorded on a scale with a low score indicating increased mania and a high score increased depression. The data is provided below. MHPG     Affect 980           22 1209         26 1403         8 1950         10 1814          5 1280          19 1073          26 1066          12 880            23 776            28 a. Can MHPG significantly predict affect? Please support your answer. b. Please report the regression equation and then interpret the following: i. Slope – ii. Intercept – iii. R (squared)   c. Increases in MHPG cause increases in affect...true or false? Please explain.

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It is hypothesized that there are fluctuations in norepinephrine (NE) levels which
accompany fluctuations in affect with bipolar affective disorder (manic-depressive
illness). Thus, during depressive states, NE levels drop; during manic states, NE levels
increase. To test this relationship, researchers measured the level of NE by measuring the
metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG in micro gram per 24 hour) in the
patient's urine experiencing varying levels of mania/depression. Increased levels of
MHPG are correlated with increased metabolism (thus higher levels) of central nervous
system NE. Levels of mania/depression were also recorded on a scale with a low score
indicating increased mania and a high score increased depression. The data is provided
below.
MHPG     Affect
980           22
1209         26
1403         8
1950         10
1814          5
1280          19
1073          26
1066          12
880            23
776            28
a. Can MHPG significantly predict affect? Please support your answer.
b. Please report the regression equation and then interpret the following:
i. Slope –
ii. Intercept –
iii. R (squared)
 
c. Increases in MHPG cause increases in affect...true or false? Please explain.
 
 
 
 
 
 
 
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