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Individuals infected with herpes simplex virus (HSV) mount protective antibody responses directed against surface glycoproteins of the virus.   These antibodies are critical to viral clearance.  The act to neutralise any virus trying to infect a person’s cells as well as activating the classical pathway of complement and cytotoxic cell-mediated killing of infected target cells. Having a deficiency in the complement component C3 greatly impairs a person’s ability to control HSV infections.   To understand this further, you will investigate this in the lab.  Using C3-deficient mice, you infect them with HSV at day 0 and then a second time 4 weeks later. A hypothesis is a tentative answer to a scientific question and is an important part of practical experiments.  A testable hypothesis is statement that can be proved or disproved as a result of experimentation. You perform an ELISA to measure the antibody response of the C3-deficient and normal mice (referred to as wild-type – WT) infected with HSV. The results are shown in Figure 1.    Q.  Looking at Figure 1, describe the results of the ELISA.

Individuals infected with herpes simplex virus (HSV) mount protective antibody responses directed against surface glycoproteins of the virus.   These antibodies are critical to viral clearance.  The act to neutralise any virus trying to infect a person’s cells as well as activating the classical pathway of complement and cytotoxic cell-mediated killing of infected target cells. Having a deficiency in the complement component C3 greatly impairs a person’s ability to control HSV infections.   To understand this further, you will investigate this in the lab.  Using C3-deficient mice, you infect them with HSV at day 0 and then a second time 4 weeks later. A hypothesis is a tentative answer to a scientific question and is an important part of practical experiments.  A testable hypothesis is statement that can be proved or disproved as a result of experimentation. You perform an ELISA to measure the antibody response of the C3-deficient and normal mice (referred to as wild-type – WT) infected with HSV. The results are shown in Figure 1.    Q.  Looking at Figure 1, describe the results of the ELISA.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Individuals infected with herpes simplex virus (HSV) mount protective antibody responses directed against surface glycoproteins of the virus.

 

These antibodies are critical to viral clearance.  The act to neutralise any virus trying to infect a person’s cells as well as activating the classical pathway of complement and cytotoxic cell-mediated killing of infected target cells. Having a deficiency in the complement component C3 greatly impairs a person’s ability to control HSV infections.

 

To understand this further, you will investigate this in the lab.  Using C3-deficient mice, you infect them with HSV at day 0 and then a second time 4 weeks later.

A hypothesis is a tentative answer to a scientific question and is an important part of practical experiments.  A testable hypothesis is statement that can be proved or disproved as a result of experimentation.

You perform an ELISA to measure the antibody response of the C3-deficient and normal mice (referred to as wild-type – WT) infected with HSV. The results are shown in Figure 1. 

 

Q.  Looking at Figure 1, describe the results of the ELISA.

X Word File Edit View Insert Format Tools Table V US Reading List bartleby® 8 < G Add Image US Assignments: Combating Dise... learn Get live help whenever you need from online tutors! Try bartleby SEARCH LIBRARY 1,191 write W ||| Window Help bartleby.com EESubmit your question to our 24/7 subject matter experts with Masters and PhDs and get IMI A hypothesis is a tentative answer to a scientific question and is an important part of pi hypothesis is statement that can be proved or disproved as a result of experimentation BIU X² X₂ tutor ASK AN EXPERT 7 Paraphrasing Tool | QuillBo Ix CONTINUE study resources LIVE CHAT ((( Home Paste Page 1 of 2 OOO AutoSave OFF Insert Draw Design Layout X A A 000 Calibri (Bo... B I U Anti-HSV IgG Ab (μµg/ml) 000 V 12 V ✓ ab x₂ x² 10³ 10² 10¹ - 10⁰ 378 words QX Primary infection de 12 References Aa ✓ AA Mailings >> Tell me 3 4 5 Secondary infection X Figure 1 Focus WC7140 - Co... - Saved to my Mac Paragraph V A Q Styles Dictate V Wild-type C3 6 7 8 Weeks post- vaccination Sun 14 Aug 10:35 O Share Editor Comments + 321%
Transcribed Image Text:X Word File Edit View Insert Format Tools Table V US Reading List bartleby® 8 < G Add Image US Assignments: Combating Dise... learn Get live help whenever you need from online tutors! Try bartleby SEARCH LIBRARY 1,191 write W ||| Window Help bartleby.com EESubmit your question to our 24/7 subject matter experts with Masters and PhDs and get IMI A hypothesis is a tentative answer to a scientific question and is an important part of pi hypothesis is statement that can be proved or disproved as a result of experimentation BIU X² X₂ tutor ASK AN EXPERT 7 Paraphrasing Tool | QuillBo Ix CONTINUE study resources LIVE CHAT ((( Home Paste Page 1 of 2 OOO AutoSave OFF Insert Draw Design Layout X A A 000 Calibri (Bo... B I U Anti-HSV IgG Ab (μµg/ml) 000 V 12 V ✓ ab x₂ x² 10³ 10² 10¹ - 10⁰ 378 words QX Primary infection de 12 References Aa ✓ AA Mailings >> Tell me 3 4 5 Secondary infection X Figure 1 Focus WC7140 - Co... - Saved to my Mac Paragraph V A Q Styles Dictate V Wild-type C3 6 7 8 Weeks post- vaccination Sun 14 Aug 10:35 O Share Editor Comments + 321%
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