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- 2) When conjugated aldehydes or ketones are attacked by a nucleophile, often more than one product forms. Please show resonance structures to explain which positions in the following conjugated ketone can react with NaBH4. Which product(s) can form? + H н-вн Na H CH3OHPleas explain how this process occurs. Identify SN1, SN2, E2, E1, nucleophiles and electrophiles.Draw the structure for the nucleophilic substitution product.
- 1. Rank the following substances in order of increasing reactivity towards nucleophilic acyl substitution (the least reactive is 1 and the most reactive is 5). 요 OPh HO1. Predict the product and provide the mechanism for the following reversible nucleophilic addition. NaOH in H₂O 2. Predict the product and provide the mechanism for the following reversible nucleophilic addition. H2SO4 (cat) H EtOHWhat is the source of the nucleophilic attack? How does the oxygen get protonated? What causes the elimination reaction?
- This reaction is an example of conjugate addition of a nucleophile to an a,ß-unsaturated carbonyl. CНз CHз Нао ОН Draw the two resonance structures of the enolate anion intermediate for this reaction.Which of the following nucleophiles would add to an alpha,beta-unsaturated ketone via direct addition? KCN LICH3 KOH NH,CH,CH,CH3 O HOCH₂CH₂CH3When a single compound contains both a nucleophile and a leaving group, an intramolecular reaction occurs. With this in mind, what is the structure and stereochemistry of the following reaction?