In nucleophilic acyl substitution, addition to the carbonyl by a nucleophile is followed by loss of the leaving group. O loss of the leaving group is followed by rearrangement of the carbocation. ester hydrolysis is followed by deprotonation. O protonation of the carbonyl is followed immediately by loss of the leaving grou O an SN2 reaction occurs.
In nucleophilic acyl substitution, addition to the carbonyl by a nucleophile is followed by loss of the leaving group. O loss of the leaving group is followed by rearrangement of the carbocation. ester hydrolysis is followed by deprotonation. O protonation of the carbonyl is followed immediately by loss of the leaving grou O an SN2 reaction occurs.
Chapter21: Carboxylic Acid Derivatives: Nucleophilic Acyl Substitution Reactions
Section21.SE: Something Extra
Problem 81AP
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![Question 23
In nucleophilic acyl substitution,
O addition to the carbonyl by a nucleophile is followed by loss of the leaving group.
O loss of the leaving group is followed by rearrangement of the carbocation.
O ester hydrolysis is followed by deprotonation.
O protonation of the carbonyl is followed immediately by loss of the leaving grour
O an SN2 reaction occurs.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F8f3fa575-f74a-48f1-b93c-a5040ef35469%2Fe2c889af-03db-4dd2-b8e1-6057050ef74a%2Fv6fm5gh_processed.jpeg&w=3840&q=75)
Transcribed Image Text:Question 23
In nucleophilic acyl substitution,
O addition to the carbonyl by a nucleophile is followed by loss of the leaving group.
O loss of the leaving group is followed by rearrangement of the carbocation.
O ester hydrolysis is followed by deprotonation.
O protonation of the carbonyl is followed immediately by loss of the leaving grour
O an SN2 reaction occurs.
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