In normal cells, the telomeric DNA sequences are which of the following (select one)? A. Get shorter with successive cell generations B. Get longer with successive cell generations C. Remain unchanged throughout successive cell generations D. Disappear after the first generation of daughter cells E. Sequence changed to all T in daughter cells
In normal cells, the telomeric DNA sequences are which of the following (select one)?
| A. |
Get shorter with successive cell generations |
|
| B. |
Get longer with successive cell generations |
|
| C. |
Remain unchanged throughout successive cell generations |
|
| D. |
Disappear after the first generation of daughter cells |
|
| E. |
Sequence changed to all T in daughter cells |
1. Telomere is a repetitive sequence of TTAGGG at the end of chromosomes.
2. During DNA replication, a short piece of RNA attaches at the end of DNA strand to initiate elongation process of DNA replication. At the end of replication the primer is removed
3. Since the primer does not attach to the very end of the DNA sequence, DNA gets shorter by 50-250 bp by each turn of replication.
4. To protect the DNA, telomerase enzyme facilitates to add repetitive sequence at the end and the sequence is called telomere.
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