In many different human diseases, there is an abnormal accumulation of mis-folded proteins within (or surrounding) cells. This can induces a stress response in cells that, when prolonged, is thought to be a causative factor in certain neurodegenerative diseases. Which organelle is likely malfunctioning and allowing for the buildup?
In many different human diseases, there is an abnormal accumulation of mis-folded proteins within (or surrounding) cells. This can induces a stress response in cells that, when prolonged, is thought to be a causative factor in certain neurodegenerative diseases. Which organelle is likely malfunctioning and allowing for the buildup?
There is a molecular pathway implicated in various neurodegenerative diseases is the misfolding, aggregation, and accumulation of proteins in the brain. Accumulation of misfolded proteins leads to synaptic dysfunction, neuronal apoptosis, brain damage, and disease. Neurodegenerative diseases are some of the disorders affecting thinking, skilled movements, feelings, cognition, and memory. This group of diseases includes common disorders such as Alzheimer disease, and Parkinson disease and other rare disorders such as Huntington disease, spinocerebellar ataxia, transmissible spongiform encephalopathies, and amyotrophic lateral sclerosis.
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