In beta oxidation of fatty acids in mitochondria, ubiquinone (via FAD/ FADH2) from the respiratory chain acts as an oxidizing agent in oneoxidation step and NAD + as an oxidizing agent in the other oxidationstep. Discuss the exchange of ATP per oxygen molecule consumed inthe breakdown of fatty acids into acetyl-COAI in relation to theexchange of ATP perroxygen molecule consumed if only NADH is theelectron source for the respiratory chain.

Beta oxidation is the sequential removal of two carbon fragments from the carboxylic end of the…

Answered: In beta oxidation of fatty acids in…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

Compare the metabolic efficiencies of complete oxidation of fat (use 1,2-stearoyl-3-palmitoleoyl-glycerol as your example!) versus glucose in terms of moles of NADH equivalents (e.g., FADH2 and NADH) per gram (assume that all of the compounds of interest are in their anhydrous form) electron equivalents per gram O2 consumed per gram.
All steps in the calculations must be reported, incomplete reporting of these leads directly to return. Make a theoretical calculation of how many ATP molecules can be formed from the degradation of an acetyl-CoA molecule to carbon dioxide and water if the entire proton gradient across the mitochondria's inner membrane can be used for ATP production and when the ATP synthase has 15 c-subunits.
If oxidation of acetyl-CoA yields 10 ATPs per mole through the citric acid cycle, how many ATPs will be derived from the complete metabolic oxidation of 1 mole of alanine in a mammal? Would the corresponding energy yield in a fish be higher or lower? Why? How much energy would be derived from the metabolic oxidation of 1 mole of isoleucine to CO2, H2O, and NH3? Of tyrosine?
Write a balanced equation for HMP Pathway where by Fructose 6 phosphate and glyceroldehyde 3 phosphate generated by each passage through HMP is catabolized by glycolysis and TCA cycle to NADH and CO2.
if each NADH generates 3 ATP molecules and each FADH2 generates 2 ATP molecules, calculate the number of ATP molecules generated from one saturated 10-carbon fatty acid Determine the number of repetitions of the β‑oxidation spiral needed to completely degrade the fatty acid to acetyl-SCoAacetyl-SCoA (acetyl-CoA)(acetyl-CoA) . Calculate the ATPATP produced by the acetyl-SCoAacetyl-SCoA molecules in the citric acid cycle. Calculate the ATPATP produced from the FADH2FADH2 and NADHNADH produced from β‑oxidation. Add the ATPATP generated (from step 2 and 3), and subtract the ATPATP needed to activate the fatty acid.
State whether the following statements are True or False, If False, explain why 5.1 Oxaloacetate is formed by the oxidation of L-malate 5.2 An overstimulation of the citric acid cycle will cause an overproduction of oxygen 5.3 The citric acid cycle occurs in the mitochondrial matrix of prokaryotes and eukaryotic 5.4 NADH and ADP are high energy electron carriers which can be utilised in the electron transport chain
The reduction potentials of iron in each of the cytochromes in the electron transport complexesvary from 0.The reduction potentials of iron in each of the cytochromes in the electron transport complexes vary from 0.1 V to 0.39 V. Explain why these different values are necessary for the operation of this process
Why does FAHD2 oxidation give 1.5 ATP while NADH oxidation gives 2.5 ATP? Explain this in relation to ETC.
FAD is a stronger oxidant than NAD*; FAD has a higher standard reduction potential than NAD*. Yet in the last reaction of the pyruvate dehydrogenase complex, FADH; bound to Ez is oxidized by NAD*. Explain this apparent paradox.
Nicotinamide nucleotide transhydrogenase (NNT) in the inner mitochondrialmembrane catalyzes the reaction NADH + NADP+ → NAD+ + NADPH to generate the NADPH needed for certain reactions that help destroy reactive oxygen species. (a) Explain why the NNT reaction cannot be driven primarily by the diff erence in substrate reduction potentials (Δℰ). (b) In fact, the NNT reaction is driven by proton translocation across the membrane (from outside to inside). How does operation of the transhydrogenase aff ect the effi ciency of oxidative phosphorylation?
In the mitochondrial disease MNGIE a deficiency of thymidine phosphorylase causes dTTP to accumulate in mitochondria. Describe the mechanism by which this occurs. A secondary effect is depletion of mitochondrial dCTP pools. Describe a plausible mechanism for this effect.
Draw the mechanism for the complete oxidation of a C-7 saturated fatty acid. Indicate the yield of ATP equivalents assuming there are 8 c-subunits in the ATP synthase, and NADPH = NADH.

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