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How would you expect the mitotic index of a cancer tissue to compare with that of the onion root tip?
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- What is required to enable a cancercell to metastasize?What is the difference between saying that cancer is inherited and saying that the predisposition to cancer is inherited?Cancer is a major public health problem. Both inherited genes and environmental factors play a role in the development of cancer. Associations have also been documented between environmental pollutants and cancer. In general, cancers caused by occupational or environmental exposures are pathologically and clinically indistinguishable from other cancers. However, some cancers have a very high probability of being occupationally related, such as angiosarcoma of the liver due to vinyl chloride exposure, and mesothelioma from asbestos fiber exposure. Documentation of exposures that cause cancer relies heavily on epidemiological studies. Unfortunately, there are complicating factors, such as the long latency period before the cancers are actually diagnosed, well after many other workers had already been exposed. Therefore, what must the prevention of occupational and environmental cancers rely upon to predict effects on humans and establish limits for human exposure?
- How is an inmortal cancer cell line different from a regular cancel cell line ?In order for certain cancers to propagate, they require a growth factor known as Vascular Endothelial Growth Factor (VEGF). What does VEGF signal the cell to do and how does this promote the propagation of cancer cells?In your own words, explain how cancer cells differ from normal cells in regard to the following: Molecular controls of the cell cycle (include Cdk and Cdk/cyclin complexes, p53 gene/protein, Rb gene/protein in response)
- Cancer can arise spontaneously, but it can also be induced as a result of environmental factors such as sun exposure, infections, and tobacco smoking. If you were asked to help allocate resources to cancer research, what emphasis would you place on research to find cancer cures, compared to that placed on education about cancer prevention?Unlike many other diseases, the vast majority of cancers in humans are not transmissible - meaning a person can’t ‘catch cancer’ from someone else. How does a person get cancer, then? Starting with a normal (non-cancerous) cell, describe a possible sequence of events that could eventually result in metastasized cancer, including the genes, structures or processes involved.Although cancer is not a contagious disease in humans or other vertebrates, there have been rare cases in which cancers have spread from one organism to another. Describe three cases of these contagious cancers and what conditions might have led to their appearance. For an introduction to this topic, see http:// www.cancer.org/cancer/cancerbasics/is-cancer-contagious.
- Which of the following is not a characteristic of cancer cells? an increase in density dependent inhibition an increase in telomere length a decrease in DNA repair a decrease in cell adhesion molecules an increase in chromosome abnormalitiesIn the experiment of cell fusion, when tumor cells were fused with normal cells, the initially formed tetraploid cells (or subsequently arising sub-tetraploid cells) were discovered to have lost the ability to form tumors. What is the explanation for this observation?Put a checkmark next to any of the following scenarios that would make it MORE likely that a cell would divide when it is not supposed to, increasing the chance that it would become cancerous. CHOOSE ALL THAT APPLY. A) A tumor suppressor gene is over-expressed B) A cyclin gene is mutated so that it is expressed at all times during the cell cycle C) A cyclin-dependent kinase gene is mutated so that in the Cdk is no longer dependent on its cyclin D) A Cdk gene is mutated so that the Cdk protein is not made E) Mutation of an oncogene that causes it to no longer be expressed F) A proto-oncogene gene is expressed at higher than normal levels G) The p53 gene is mutated so that no p53 protein is made
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