Numerous computational methods are used in bioinformatics, that include sequence and structural alignment, database designing and data mining, macromolecular geometry, development of phylogenetic trees, prediction of protein structure and function, gene discovery, and clustering of expression data.
Significance -
This scientific subdiscipline is connected to genetics and genomics, using computer technology to analyse and share biological information, (like DNA and amino acid sequences).
The functions of bioinformatics -
(1) software tools and algorithms development
(2) analysis and interpretation of biological data using different software tools and algorithms.
The main drawbacks of using bioinformatics to find new cellulase genes are -
(1) a reduced ability to predict specific enzyme characteristics, such as enzyme activity, thermostability, etc., which is frequently based on known enzyme homology; and
(2) a complex microbial community that impedes cellulase enzyme discovery efforts using a bioinformatics approach by preventing the assembly of full-length gene assemblages.
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